excluded, in particular, inactivation through reversible binding to a protein Turning to the analogs of (I): (V) is highly toxic to mammals both orally and by skin application; obviously, penetration and transport are adequate to deliver sufficient compound to overwhelm the detoxification mechanisms and cholinesterase. compound I11 is toxic orally but relatively safe dermally, suggesting that cuticular penetration limits the availability of compound 111.Compound I1 is safer than (III), slightly Receir cd f o r rci,ieLt, August 76, 7965. Accepted .\larch 7. 1!)66. Dir'ision of Agricultural nnd Food Chrmishy. ili7th .Weeling, ,4CS, L)e/rnif. .tlich., .Iprii 1965.
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