excluded, in particular, inactivation through reversible binding to a protein Turning to the analogs of (I): (V) is highly toxic to mammals both orally and by skin application; obviously, penetration and transport are adequate to deliver sufficient compound to overwhelm the detoxification mechanisms and cholinesterase. compound I11 is toxic orally but relatively safe dermally, suggesting that cuticular penetration limits the availability of compound 111.Compound I1 is safer than (III), slightly Receir cd f o r rci,ieLt, August 76, 7965. Accepted .\larch 7. 1!)66. Dir'ision of Agricultural nnd Food Chrmishy. ili7th .Weeling, ,4CS, L)e/rnif. .tlich., .Iprii 1965.

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The name stellasterol was assigned in 1915 by Kossel and Edlbacher (1) to a di-unsaturated sterol of the probable formula C27H44O, w'hich occurs together with astrol in the unsaponifiable matter of the starfish Asterias rubens. The suggestion has been made in a previous communication of this series (2), that asteriasterol (3), the sterol of Asterias forbesi, is a mixture of astrol, stellasterol, and other ill-identified sterols. Since then it has been shown by the present authors (4) that astrol is identical with batyl alcohol. A resumption of the

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