Craniosynostosis is a skull malformation because of premature fusing of one or more cranial sutures. The most common types of craniosynostosis are scaphocephaly (with the sagittal suture fused) and trigonocephaly (with the metopic suture fused). In this paper we describe and discuss how finite element analysis and three-dimensional modeling can be used for preoperative planning of the correction of craniosynostosis and for the postoperative evaluation of the treatment results. We used the engineering software MIMICS MATERIALISE to obtain three-dimensional geometry from computed tomography scans, and applied finite element method for the sake of biomechanical analysis. These simulations help to improve the surgical treatment, making it more accurate, safer, and faster.

this study analyzed morphometric and hemodynamic parameters of aneurysmal and non-aneurysmal middle cerebral artery (McA) bifurcations and their relationship with optimal values derived from the principle of minimum work (PMW). The study included 96 patients with MCA aneurysm and 94 controls. Aneurysm patients presented with significantly higher values of the radius and cross-sectional area of the McA trunk, angle between the post-bifurcation branches (α angle) and volume flow rate (VFR) and had significantly lower values of junction exponent and pulsatility index than the controls. The Φ 1 and Φ 2 angles (angles between the MCA trunk axis and the larger and smaller branch, respectively) and α angle in all groups were significantly larger than the optimal PMW-derived angles. The most important independent predictors of MCA aneurysm were junction exponent (odds ratio, OR = 0.42), α angle (oR = 1.07) and VFR (OR = 2.36). Development of cerebral aneurysms might be an independent effect of abnormalities in hemodynamic and morphometric factors. The risk of aneurysm increased proportionally to the deviation of morphometric parameters of the bifurcation from their optimal pMWderived values. The role of bifurcation angle in aneurysm development needs to be explained in future research as the values of this parameter in both aneurysm patients and non-aneurysmal controls in were scattered considerably around the pMW-derived optimum.

This study investigated how spatial projection systems influences body balance including postural stability. Analyzing precisely defined frequency bands of movements of the center of pressure makes it possible to determine the effectiveness of the balance system’s response to disruptions and disorders and may be used as an indicator in the diagnosis of motor dysfunction. The study involved 28 participants for whom the center of pressure was assessed in a test with open eyes, closed eyes and with virtual reality projection. Percent distributions of energy during wavelet decomposition were calculated. Changes in body stability were determined for the virtual reality tests and these changes were classified as an intermediate value between the open-eyes test and the closed-eyes test. The results indicate the importance of using safety support systems in therapies involving Virtual Reality. The results also show the necessity of measurements times in stabilographic evaluations in order to conduct a more thorough analysis of very low frequencies of the center of pressure signal.

Understanding mechanisms of spinal cord injury and repair requires a reliable experimental model. We have developed a new device that produces a partial damage of spinal cord white matter by means of a precisely adjusted stream of air applied under high pressure. This procedure is less invasive than standard contusion or compression models and does not require surgical removal of vertebral bones. We investigated the effects of spinal cord injury made with our device in 29 adult rats, applying different experimental parameters. The rats were divided into three groups in respect to the applied force of the blast wave. Functional outcome and histopathological effects of the injury were analyzed during 12-week follow-up. The lesions were also examined by means of magnetic resonance imaging (MRI) scans. The weakest stimulus produced transient hindlimb paresis with no cyst visible in spinal cord MRI scans, whereas the strongest was associated with permanent neurological deficit accompanied by pathological changes resembling posttraumatic syringomyelia. Obtained data revealed that our apparatus provided a spinal cord injury animal model with structural changes very similar to that present in patients after moderate spinal cord trauma.

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