A chronic adverse reaction may occur in some instances of drug-induced liver injury (DILI), even despite drug cessation. In our study, we obtained records from a Spanish registry and evaluated cases of DILI with biochemical evidence of long-term damage. Chronic outcome was defined as a persistent biochemical abnormality of hepatocellular pattern of damage more than 3 months after drug withdrawal or more than 6 months after cholestatic/mixed damage. Data on 28 patients with a chronic clinical evolution (mean follow-up 20 months) between November 1995 and October 2005 were retrieved (18 female; overall mean age 55 yr) and accounted for 5.7% of total idiosyncratic DILI cases (n ‫؍‬ 493) submitted to the registry. The main drug classes were cardiovascular and central nervous system (28.5% and 25%, respectively), which, in contrast, represented only 9.8% and 13%, respectively, of all DILI cases. The most frequent causative drugs were amoxicillin-clavulanate (4 of 69 cases), bentazepam (3 of 7 cases), atorvastatin (2 of 7 cases), and captopril (2 of 5 cases). Patients with cholestatic/mixed injury (18 of 194 cases [9%]) were more prone to chronicity than patients with hepatocellular injury (10 of 240 cases; P < .031). In the case of chronic hepatocellular injury, 3 patients progressed to cirrhosis and 2 to chronic hepatitis. In the cholestatic/mixed group, liver biopsy indicated cirrhosis in 1 patient and ductal lesions in 3 patients. In conclusion, cholestatic/mixed type of damage is more prone to become chronic while, in the hepatocellular pattern, the severity is greater. Cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage. (HEPATOLOGY 2006;44: 1581-1588.)Abbreviations: DILI, drug-induced liver injury;

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Abstract-In this work, a millimeter wave microstrip frequency-mixer design based on graphene is presented. The desired frequency mixing behavior is obtained using a nonlinear component consisting in a microstrip line gap covered by a graphene layer. The circuit includes microstrip filters that have been designed to obtain a high isolation between the input and output ports. The nonlinear behavior of the frequency mixer has been experimentally evaluated in the 38.6-40 GHz input signal frequency range, for different values of the input power and local oscillator power.

The present study provides information on polyphenol intake in an elderly Mediterranean population with a level of detail that has not been achieved previously. The identification of age and lifestyle factors associated with the intake of polyphenols may be useful in future studies regarding polyphenols.

A novel fully textile-integrated antenna based on a slotted short-circuited microstrip line has been designed, manufactured and experimentally validated for its use in automobile upholsteries for dedicated short-range communications. The antenna can be manufactured using an industrial loom and a laser prototyping machine, avoiding subsequent treatments, sewing procedures or coatings. The manufactured antenna presents a central working frequency of 5.9 GHz and a 9.3% bandwith. Good agreement between simulations and measurements has been achieved.

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Two millimetre-wave textile integrated waveguides, which only differ in the employed substrate, have been designed, manufactured and experimentally characterized. Both waveguides have been conceived to be based on the conventional substrate integrated waveguide technology while being fully integrated in textile. The manufactured prototypes have been characterized by using a back to back textile integrated waveguide to rectangular waveguide transition. The theoretically predicted behaviour of the prototypes has been experimentally verified.