Free radicals play an important role in the pathogenesis of tissue damage in many clinical disorders, including atherosclerosis. This study was to investigate lipids and oxidative stress markers among women with 50 healthy non-pregnant compare with 50 healthy pregnant and 50 pregnancy-induced hypertensive subjects and correlate with cardiac troponin I (cTnI) and troponin T (cTnT). The level of plasma thiobarbituric acid reactive substances (TBARS), cTnI and cTnT levels significantly increase in pregnancy-induced hypertension compare with other groups. The level of lipids significantly altered in pregnancy-induced hypertension. Conversely, the activities of both enzymatic and non-enzymatic antioxidants were significantly decreased in pregnancy-induced hypertension compared to nonpregnant and healthy pregnant. Our data suggest that there is an imbalance between lipoperoxidation and antioxidants levels during pregnancy and preeclampsia. Serum cTnI and cTnT are elevated in women with pregnancy-induced hypertension indicating some degree of cardiac myofibrillar damage and cardiac dysfunction.

In this study we investigated the oxidative stress, antioxidants and inflammatory molecules in patients of acute myocardial infarction (AMI) with diabetes (n=50) and non-diabetes (n=50). Fifty healthy subjects were taken as control. The levels of plasma TBARS and ceruloplasmin levels were significantly high in diabetic and non-diabetic AMI patients as compared with control. On the other hand, the activities of both enzymatic and non-enzymatic antioxidants were significantly decreased in diabetic and non-diabetic AMI patients as compared with control. Inflammatory markers showed significant rise in diabetic patients as compared with controls. Our results show increased inflammation and oxidative stress in patients with AMI, and magnitude of imbalance is greater in diabetic AMI patients, possibly because of greater inflammation in diabetic patients.

The aim of the study was to investigate the levels of lipid peroxidation, and both plasma and erythrocyte antioxidant states in patients with rheumatoid arthritis. The population consisted of 60 subjects divided into two groups, 30 subjects had evidence of rheumatoid arthritis and age and sex matched healthy subjects were studied as controls. The level of plasma and erythrocyte thiobarbituric acid reactive substances (TBARS) was markedly increased in both the rheumatoid arthritis patients when compared to control subjects. The activities of plasma and erythrocyte antioxidants were significantly decreased in rheumatoid arthritis. C reactive protein, rheumatoid factor and antistreptolysin-O were significantly higher in rheumatoid arthritis patients than in healthy subjects. In conclusion, on the basis of enhanced lipid peroxidation in rheumatoid arthritis patients with concomitant failure of both the plasma, and erythrocyte antioxidants defense mechanism. These results are consistent with the underlying hypothesis that there is an imbalance between reactive oxygen species production and the antioxidant defense system in inflammatory rheumatoid arthritis disease.

Background: The aim and objective of this study was to investigate the level of serum lipids and thyroid hormonesstatus in HIV infection and AIDS patients.Methods: The population consisted of 150 subjects divided into three groups; among HIV infected patients fiftycases, AIDS patient’s fifty cases and an equal numbers of age- and sex-matched healthy subjects were investigated.Results: In this study, we observed the level of serum lipids significant changes occur in AIDS patients compare toHIV infection and healthy subjects. There were no significant differences in total TT4 concentrations among the AIDSpatients when compared to HIV infection and normal healthy subjects. A measured FT4 concentration was slightlybut significantly decreased in HIV /AIDS patients. Total T3 concentrations were normal in HIV infected patients, butslightly decreased in AIDS; more important, T3 level was decreased in AIDS patients. The level of FT3 concentrationwas slightly but significantly increased in HIV infected and significantly decreased in AIDS patients. As all TSH levelswere within the normal range; however, there was a small but significantly increase in TSH levels in AIDS, and therewas a trend toward an increase in TSH levels in AIDS compared with controls.Conclusion: Thyroid dysfunction is frequent in HIV infection and with progression of disease there is a primaryhypothyroid like stage that occurs in patients with HIV infection. TT3, FT3, FT4 and serum TSH can be used as asurrogate marker of the progression of the disease.Key words: HIV; AIDS; CD4+ cell count; Thyroid function test; Lipids; Hematological TestDOI: 10.3329/jom.v11i2.5455J MEDICINE 2010; 11 : 131-136

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