Thyroid Function, Cardiac Risk Assessment Profile and Hematological Changes During HIV Infection and AIDS Patients

Pasupathi, Palanisamy; Manivannan, Perisamy; Manivannan, Uma; Deepa, M

doi:10.3329/jom.v11i2.5455

Cited by 7 publications

(9 citation statements)

References 3 publications

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“…The results were found to be statistically significant with the P < 0.001. A gradual decrease in the CD4 cell counts observed in HIV-infected and AIDS patients in the present study when compared to the controls were still higher than the mean values observed in the two studies conducted by Pasupathi et al .,[ 16 23 ] who recorded a mean CD4 cell count of 394 in HIV-infected and 191 in AIDS patients and 375 in HIV-infected and 150 in AIDS patients, although the results obtained were found in accordance with the results obtained in the studies conducted by Tiwari et al .,[ 19 ] who recorded a mean value of 281 cells per mm 3 , and Sharma et al .,[ 24 ] who observed a mean CD4 cell count of 622.4 in HIV-infected and 245.39 in AIDS patients as against 798.81 in the control group. The values obtained in the present study were found to be slightly higher than the values obtained in the study conducted by Gaurav et al .,[ 9 ] who divided the patients based on their CD4 cell counts into three groups with Group I (10–300), Group II (301–600) and Group III (>600) and obtained a mean of 163.43 in Group I, 325 in Group II and 502.33 in Group III.…”

Section: Discussionsupporting

confidence: 81%

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CD4 cell counts and oral manifestations in HIV infected and AIDS patients

Ratnam

Nayyar

Reddy³

et al. 2018

J Oral Maxillofac Pathol

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Context:Acquired immunodeficiency syndrome (AIDS) is an acronym for AIDS caused by a retrovirus known as human immunodeficiency virus (HIV) which breaks down the body's immune system leaving a patient vulnerable to a host of life-threatening opportunistic infections, neurological disorders or unusual malignancies. According to estimates by the World Health Organization and UNAIDS, 35 million people were living with HIV globally at the end of 2013. The first AIDS case in India was detected in 1986. Seldom studies have been conducted correlating these parameters with oral manifestations in the Indian population.Aim:The present study was carried out to evaluate the CD4 cell counts and oral manifestations in HIV-infected and AIDS patients and to correlate them with the seronegative controls.Methodology:This was a cross-sectional, hospital-based study on individuals who were divided into three groups, Group A consisting of 500 patients who were healthy controls without any systemic illness; Group B consisting of 500 patients who were diagnosed as HIV infected and Group C consisting of 500 patients diagnosed as AIDS patients depending on their CD4 cell counts. The permission from the Ethical Committee of the Institution as well as Superintendent of Government Hospital was obtained. Evaluation of CD4 cell counts in HIV-infected and AIDS patients was done using CyFlow Counter.Results:The results were found to be statistically significant with the P < 0.001 for the CD4 cell counts. Oral manifestations revealed varied results with different levels of significance.Conclusion:CD4 cell counts were significantly altered in HIV-infected and AIDS patients when compared with the controls while oral manifestations revealed varied results with different levels of significance.

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Section: Discussionsupporting

confidence: 81%

“…Pasupathi et al . [ 16 ] and Srirangaraj and Venkatesha[ 17 ] estimated the CD4 cell counts using Fluorescence Activated Cell Sorter (FACS) Count System. Gaurav et al .…”

Section: Discussionmentioning

confidence: 99%

CD4 cell counts and oral manifestations in HIV infected and AIDS patients

Ratnam

Nayyar

Reddy³

et al. 2018

J Oral Maxillofac Pathol

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show abstract

“…The results were statistically significant. The gradual decrease in the CD4 cell counts observed in HIV-infected and AIDS patients in the present study was still higher than the mean values observed in studies by Pasupathi et al [ 16 , 23 ], recording a mean CD4 cell count of 394 and 375 in HIV-infected and 191 and 150 in AIDS patients. Our results were in accordance with the results obtained in research conducted by Tiwari et al [ 19 ], reporting a mean value of 281 cells/mm 3 , and Sharma et al [ 24 ] that observed a mean CD4 cell count of 622.4 in HIV-infected and 245.39 in AIDS patients against 798.81 in the control group.…”

Section: Discussioncontrasting

confidence: 83%

“…Ghate et al [ 15 ] estimated the CD4 cell counts using a formula. Pasupathi et al [ 16 ] and Srirangaraj and Venkatesha [ 17 ] estimated the CD4 cell counts using the Fluorescence-Activated Cell Sorter (FACS) count system. Sharma et al [ 11 ] estimated the CD4 cell counts using flow cytometry.…”

Section: Discussionmentioning

confidence: 99%

CD4 Cell Counts, Lipid Profile, and Oral Manifestations in HIV-Infected and AIDS Patients

Koduri

Malathi²,

Kv³

et al. 2020

fid

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Objectives: The present study aimed to evaluate CD4 cell counts, lipid profile, and oral manifestations in human immunodeficiency virus (HIV)-infected and acquired immune deficiency syndrome (AIDS) patients and their correlation with seronegative controls. Materials and Methods: In this cross-sectional, hospital-based study, there were three groups of subjects: group A consisting of 500 healthy patients (controls), group B composed of 500 HIV-infected patients, and group C comprised of 500 AIDS patients based on their CD4 cell counts. CD4 cell counts were assessed using the CyFlow counter. Lipid profile was evaluated with the Erba EM 360 analyzer. Results: The results were statistically significant for CD4 cell counts (P<0.001). The levels of total cholesterol (TC) and low-density lipoproteins (LDLs) were significantly decreased while triglycerides (TGs) and very-low-density lipoproteins (VLDLs) were significantly increased in AIDS patients compared to the controls and HIV-infected patients. Various results were obtained regarding oral manifestations with different levels of significance. Conclusion: CD4 cell counts, TC, LDLs, TGs, and VLDLs were significantly changed in HIV-infected and AIDS patients compared to the controls.

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“…Palanisamy P et al concluded that thyroid dysfunction is frequent in HIV infection and that with progression of disease there is a primary hypothyroid like stage that occurs in patients with HIV infection. 13 Therefore free T3, free T4 and serum TSH can be used as a surrogate marker of progression of the disease. Thongam S et al, reported that thyroid dysfunction may be a marker of severity or progression of HIV.…”

Section: Resultsmentioning

confidence: 99%

Study of thyroid profile in seropositive HIV adults patients on HAART regimen

et al. 2017

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Background: Subtle alterations in thyroid function tests are more common in HIV infection and at times detectable in the early phase of disease and as well as in late phases. However, there is paucity of Indian studies.Methods: This cross-sectional study was carried out among adult HIV positive patients attending OPD and IPD of tertiary care hospital in collaboration with ART-plus center over a period of 21months. 100 adult HIV positive patients were interviewed and clinically examined. On the basis of CD4 count patients were divided into 3 groups {0-200 (Group A), 201-350 (Group B) and >350 cells/mm3 (Group C)}. Subjects were also divided into two group based on type and duration of HAART regimen.Results: Out of 100 patients included in the study 68% were males, 73% married, 12% had subclinical hypothyroidism, out of 6% of overt hypothyroidism subjects 5% were females. Among the 3 groups, thyroid abnormalities were found to be more common in group B followed by Group A and C. Patients on TLE regimen had 14% thyroid abnormalities as compared to 4% in ZLN group.Conclusions: Subclinical hypothyroidism and overt hypothyroidism are the commonest thyroid abnormality seen, more commonly in females. CD4 counts have direct association with free T3 and free T4 and inverse association with Serum TSH level indicating trend for hypothyroidism as HIV disease progresses. Thyroid abnormalities vary with the type and duration of HAART regimen.

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Thyroid Function, Cardiac Risk Assessment Profile and Hematological Changes During HIV Infection and AIDS Patients

Cited by 7 publications

References 3 publications

CD4 cell counts and oral manifestations in HIV infected and AIDS patients

CD4 cell counts and oral manifestations in HIV infected and AIDS patients

CD4 Cell Counts, Lipid Profile, and Oral Manifestations in HIV-Infected and AIDS Patients

Study of thyroid profile in seropositive HIV adults patients on HAART regimen

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