Sabalingam et al.: Dextrinized Starch-starch as Exclusive Tablet Fillers Traditional tablet filler combinations, lactose-maize starch were replaced with a new dextrinized maize starch-maize starch filler combination. Dextrinization process under controlled conditions was targeted for this purpose and specifications were determined for the dextrinized product. Granules were prepared by wet granulation method using the new filler combination. Placebo tablets T1 were first prepared with lactose-maize starch filler combination as a model. Based on the properties of resulting tablets, lactose was replaced with dextrinized maize starch, introduced a different binder and the active ingredient furosemide anticipating a tablet of acceptable quality. The flow properties of dextrinized maize starch had improved over maize starch with an angle of repose of 40°. Hausner ratio and Carr's index of dextrinized maize starch and lactose were found to be 1.34, 1.54, and 25.45, 35.24 %, respectively favourable to the former. The placebo tablets (T2) prepared with the new filler combination using 12.0 % w/w maize starch binder resulted in unacceptable hardness and friability. However, furosemide tablets (T3) prepared with the new filler combination and the binder solution of low substituted hydroxypropyl cellulose 3.2 % w/w showed excellent physical properties. The study shows that dextrinized maize starch and maize starch filler combination without lactose could be employed successfully in tablet manufacture.
Bergenin was isolated as the major active constituent from the leaves of Flueggea leucopyrus Willd. The result of this study also provides for the use of F.leucopyrus as a novel source for the commercial supply of bergenin to the global market as bergenin is a medicinal agent required for the production of various pharmaceutical formulations used in the treatment of a variety of disorders.
52control of products derived from the fruits of A. carambola.
Conclusion:The results of this study demonstrate potential use of scopoletin in the development of drugs of natural origin in the treatment of diabetes. The results could also be used in the rationalization of ethnomedical use of the fruits of A. carambola.
Purpose:The astringent activity of tannins is due to their ability to bind with proteins which in turn contributes to their antimicrobial properties. The study aimed at determining the correlation between the composite astringent power of folklore plant materials and selected herbal formulations in relation to their antimicrobial activity. Protein precipitating ability (Astringent Power) and Tannic Acid Astringent Equivalents of extracts of the materials were determined. Method: A protein precipitation assay was designed to determine the Tannic Acid Astringent Equivalents of the samples. Antimicrobial activity was determined by agar disc diffusion assay with Escherichia coli and Staphylococcus aureus. Results: Folklore materials and formulations showed strong negative correlation coefficients with Tannic Acid Astringent Equivalent values and antibacterial activities. Values observed for the folklore materials were, S. aureus (r = -0.937) and E. coli (r = -0.825) and for the formulations S.aureus (r = -0.9825) and E.coli (r = -0.8774). A new term 'very tender coconut' was introduced to describe Gobalu (Sinhala).
Conclusion:The folklore materials and marketed formulations have a strong correlation between composite astringent activities with their antimicrobial powers. High astringent activity corresponds with high antimicrobial activity justifying their ethnobotanical medicinal applications.
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