Isolation of bergenin from the leaves of Flueggea leucopyrus willd (katupila) – a novel method of obtaining bergenin

Wijayabandara, M.D.J.; Choudhary, Muhammad Iqbal; Wijayabandara, M. D. L. O.

doi:10.4038/pjsl.v5i0.3

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Cancer patients take decoctions prepared by boiling of leaves in water or as fresh or with traditional medicine recipes to improve the condition and cure the cancers. Among many studies reported on F. leucopyrus on its anti-cancer activities, chemical compositions [4] and anti-oxidant activities, the followings are highlighted; anti-oxidant and anti-proliferative activity of aqueous extract of leaves against human Hep-2 cells by Preethy Soyza et al [5], cytotoxic and apoptotic effect of the decoction of the aerial part of plant on Human Endometrial Carcinoma (AN3CA) Cells by Samarakoon et al, [6] immunomodulatory activity of the plant and identification of bergenin as the active compound by Wijabandara et al, [7], [8] growth inhibitory activities against MCF-7 and MDA-MB-231 breast cancer cell lines and P-388 cell lines by Monkodkaew et al [8], [9] etc.…”

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confidence: 99%

Anti-cancer activity of <em>Fluggea leucopyrus</em> willd (Katupila) against human ovarian carcinoma and characterization of active compounds

Bulugahapitiya

Munasinghe

Hettihewa

et al. 2020

J. Sc.

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Fluggea leucopyrus Willd has been used in the treatment for cancers in the traditional system of medicine in Sri Lanka. This study was aimed on evaluation of anti-cancer activity of F.leucopyrus against Human Ovarian carcinoma and identification of active compounds. Anti-cancer activity of ethyl acetate (EtoAc) extract of leaves and two compounds isolated from EtoAc extract were evaluated using MTS and hTERT assays on Human Ovarian carcinoma (A 2780). MTS assay showed a significant anti-proliferation activity giving IC50 (concentration of extract/compound that inhibits 50% of the activity) values of 36.35±0.17µg/mL, 12.36±1.0 µg/mL and 48.53±1.43 µg/mL for EtoAc extract and two compounds (compound-1 & compound-2) respectively. A rapid depletion of hTERT content in Human Ovarian cancer cells was observed for the compound-2 with the concentration range 50-200 µg/mL. The compounds-1 was identified as bergenin, a known compound, whereas the compound-2 was identified as a diastereoisomer of bergenin (at C-9 and C-14,) with the help of NMR and Mass spectral data, and with the comparison of reported data. Brine Shrimp Lethality assay for EtoAc extract showed LC50 (Lethal concentration) values of 2779.63 µg/mL, implying that no toxicity of plant extract towards brine shrimp. As conclusion, anti-cancer activity of leaves of F. leucopyrus against Human Ovarian cancers is confirmed in this study, and bergenin and its isomer were identified as the responsible compounds for the anticancer activity of this plant.

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Section: Introductionmentioning

confidence: 99%

Anti-cancer activity of <em>Fluggea leucopyrus</em> willd (Katupila) against human ovarian carcinoma and characterization of active compounds

Bulugahapitiya

Munasinghe

Hettihewa

et al. 2020

J. Sc.

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Functional Foods and Health

Madhujith

Wedamulla

2020

Agricultural Research for Sustainable Food Systems in Sri Lanka

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Medicinal plants used in cancer treatment: A survey conducted among traditional Ayurveda medical practitioners in Sri Lanka

Dunukara¹,

Samarakoon²,

Uluwaduge

2022

IJKIU

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Majority of deaths worldwide have been caused by noncommunicable diseases, with cancer as the second leading cause. Plant-based cures have become increasingly popular because current synthetic pharmaceuticals and other medications have demonstrated severe side effects, leading to less patient compliance and treatment failure. Furthermore, for most cancer types, there is no permanent cure. Sri Lankan traditional practitioners employ natural plant remedies to treat and cure malignancies, drawing on a long history of Ayurveda treatments and ancestral wisdom. These practitioners use different extraction processes, different parts of the same plant, and different modes of administration of the same herb. This descriptive cross-sectional study identifies commonly utilized botanicals with anticancer properties by traditional ayurvedic practitioners in Sri Lanka. The snowball approach and purposive sampling were used to select medical practitioners for this study. The survey was conducted among 18 traditional ayurvedic practitioners, and from the survey, 120 plants that the practitioners used for cancer therapy were identified. Of those 120 plants, the repetitive plants were shortlisted for ten plants. The most commonly used plants identified in this survey were Flueggea leucopyrus, Curcuma longa, Aegle marmelos, Abrus precatorius, Phyllanthus emblica, Zingiber officinale, Annona muricata, Aloe vera, Manihot esculenta, and Solanum melongena. Most medicinal plants used for cancer treatment were from the family Fabaceae.

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Isolation of bergenin from the leaves of Flueggea leucopyrus willd (katupila) – a novel method of obtaining bergenin

Cited by 3 publications

References 4 publications

Anti-cancer activity of <em>Fluggea leucopyrus</em> willd (Katupila) against human ovarian carcinoma and characterization of active compounds

Anti-cancer activity of <em>Fluggea leucopyrus</em> willd (Katupila) against human ovarian carcinoma and characterization of active compounds

Functional Foods and Health

Medicinal plants used in cancer treatment: A survey conducted among traditional Ayurveda medical practitioners in Sri Lanka

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