Electrically conducting polymers are novel class of synthetic metals that combine the chemical and mechanical properties of polymers with the electronic properties of metals and semi-conductors. Polyaniline (PANI) is one of the most intensively studied conducting polymers during the last decade. It is highly conducting and easy to synthesize both chemically as well as electrochemically. The chemical method has a great importance since it is very feasible route for the mass production of PANI. The present investigation is dedicated for the synthesis, electrochemical characterization and application of fly ash doped PANI for the anti-corrosive property. The electrochemical behavior study by cyclic voltammetry (CV) revealed the red-ox behavior of PANI composite. The study of mild steel corrosion phenomenon has become important particularly in acid media. The inhibitive properties of PANI-FA 45% composite on the corrosion of mild steel strip in 0.1M HCl were investigated using electrochemical techniques like polarization method and electrochemical impedance spectroscopy (EIS). A good barrier allows very little flow of current thereby showing high resistance impedance measurements for the prepared composite.
The main objective of the present study was to design a controlled release dosage form for an oral anti diabetic drug i.e. repaglinide employing polymers like eudragit s- 100. One of the other objective of this present study was to increase the biological half-life the drug by formulating into microspheres. The microspheres of repaglinide were prepared by solvent evaporation method by using eudragit s-100 and ethyl cellulose as polymers with different concentrations. Formulations (F1-F10) were prepared and evaluated for various micrometric properties and it was observed that though all the formulations were exhibited good flow properties, The F5 formulation exhibits higher in- vitro buoyancy time and entrapment efficiency which is considered for in- vitro and mucoadhesive studies. The FTIR results reveal that there was no interaction between the drug and the excipients. The in- vitro release profiles of F1-F5 indicated that all formulations showed controlled release over an extended period, with acceptable release kinetics. Among the all formulations F5 were considered as a promising candidate for sustain release of repaglinide.
Nano materials such as nanoparticles, nano capsules, nano emulsions, nano suspensions, nano spheres, solid lipid nanoparticles, dendrimers, nano tubes, nano shells, nano wires, nano pores, and quantum dots have been used extensively for delivery of therapeutic agents. Protein nanocapsules have gained significance as vehicles for targeted drug delivery due to improved ease of administration, medical imaging, gene delivery, and increased half-life of drug. Nano materials and devices are used for addressing medical problems and have established enormous potential for, subcutaneous imaging without surgical incisions. They are used in imaging of liver, lymph nodes, bone marrow, monitoring of many serious illnesses, including cancer, CVS disorders, neurological disorders, HIV/AIDS, and diabetes. They are employed as solubilizing agent for water-insoluble drugs by emulsification and designing of essential oil protein complexes which paved the path for using nano materials in drug delivery with prolonged blood circulation times. PLGA and albumin nanoparticles are considered to be a potential drug carrier with good biodegradability, biocompatibility, and non toxic nature. Eucalyptus oil contains 1,8-Cineol and ?-pinene as chief ingredients. Eucalyptus oil is known for healing of inflammation, pruritus, abscesses, sepsis, bacterial infections, blisters, boils, chicken pox, congestion, fungal infections, herpes (cold sores) and ulcers. However, these essential oils are unstable, volatile, which limits their use for new formulations. Therefore, this study focuses on developing a PLGA- Albumin nano carrier for the encapsulation of essential oils. The effects of process parameters such as the effect of heat and the concentrations of polymers were investigated. Various physicochemical characterizations such as SEM, FTIR, EE, and UV spectroscopy, Invitro drug release studies were performed.2 Formulation F4 containing 0.6 mg/ mL of PLGA and AL loaded eucalyptus loaded nanocapsules p
Emissions coming out from the automobile accounts for significant universal carbon emission. The reduction in the weight of the vehicle even by a kilogram can lead to a significant reduction in the carbon emissions, the use of natural fibre composites reduces the weight of the vehicle to a larger extent and minimises the problems associated with the disposal of the vehicle after its service life. The main objective of the work is to develop a light weight, comparatively eco-friendly natural fibre hybrid composite reinforced with intraply carbon +E-glass plies and unidirectional sunn hemp mat interplies and nano silica particles and to evaluate its mechanical and thermal properties for possible application in automobiles. The addition of nano silica was varied between 1wt % to 4 wt %. Mechanical properties investigation through (tensile and impact tests) and thermo mechanical investigation through dynamic mechanical analysis (DMA) and heat deflection temperature (HDT) were carried out. Activation energy of the nano composites was determined using Arrhenius model. Failure analysis of the composites was carried out with field emission scanning electron microscopy (FESEM). Mechanical and thermal properties was found to be higher for the intra-interply polymer composite reinforced with carbon+E-glass fibres and unidirectional sunn hemp mats with 3 wt %. nano silica particles addition. The results obtained in this work will be useful in designing comparatively environmentally friendlier composite structures
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