Nano materials such as nanoparticles, nano capsules, nano emulsions, nano suspensions, nano spheres, solid lipid nanoparticles, dendrimers, nano tubes, nano shells, nano wires, nano pores, and quantum dots have been used extensively for delivery of therapeutic agents. Protein nanocapsules have gained significance as vehicles for targeted drug delivery due to improved ease of administration, medical imaging, gene delivery, and increased half-life of drug. Nano materials and devices are used for addressing medical problems and have established enormous potential for, subcutaneous imaging without surgical incisions. They are used in imaging of liver, lymph nodes, bone marrow, monitoring of many serious illnesses, including cancer, CVS disorders, neurological disorders, HIV/AIDS, and diabetes. They are employed as solubilizing agent for water-insoluble drugs by emulsification and designing of essential oil protein complexes which paved the path for using nano materials in drug delivery with prolonged blood circulation times. PLGA and albumin nanoparticles are considered to be a potential drug carrier with good biodegradability, biocompatibility, and non toxic nature. Eucalyptus oil contains 1,8-Cineol and ?-pinene as chief ingredients. Eucalyptus oil is known for healing of inflammation, pruritus, abscesses, sepsis, bacterial infections, blisters, boils, chicken pox, congestion, fungal infections, herpes (cold sores) and ulcers. However, these essential oils are unstable, volatile, which limits their use for new formulations. Therefore, this study focuses on developing a PLGA- Albumin nano carrier for the encapsulation of essential oils. The effects of process parameters such as the effect of heat and the concentrations of polymers were investigated. Various physicochemical characterizations such as SEM, FTIR, EE, and UV spectroscopy, Invitro drug release studies were performed.2 Formulation F4 containing 0.6 mg/ mL of PLGA and AL loaded eucalyptus loaded nanocapsules p
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