Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide

Sivaprasad, Sobha; Alagarsamy, V.; Bharathi, M; Krishna, P.V. Murali; Kanna, K. Sandeeep

doi:10.52711/0974-360x.2021.00986

Cited by 6 publications

(1 citation statement)

References 8 publications

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“…Hollow granules (ionotropic gelation) Chitosan [25] Granules (ionotropic gelation) NA, Carrageenan [28] NA, Eudragit RL100 [85] Chitosan [26] Pectin [30] NA conjugate with bovine serum albumin [37] Hollow microspheres (solvent removal) EC [47] EC, HPMC E5 [50] EC, HPMC E50 [86] Eudragit S-100 [71] Eudragit S-100 [72] Acrycoat S 100 [74] Combination of Eudragit L100 and Eudragit RS100 [73] Polycarbonate, Polypropylene Glycol PFA [83] HPMC 3K, Eudragit RS PO [87] EC (10 cP), PVP [88] Microspheres (solvent removal) EC [89] EC, HPMC K4M [90] CA [62] Microspheres ("multiple emulsion method", solvent removal) EC, PVP [91] Tablets (direct compression) HPMC K4M, Camphor SA [55] Tablets (wet granulation) Locust bean gum, Camphor SA [41] HPC (Klucel LF), PEO (Polyox WSR N 60 K), Menthol SA [92] Tablets (shaping and freeze drying) EC, HPMC (100 cP) [49] Tablets (FDM 3D printing) HPC [60] HPMC acetate succinate, PEG 400 [93] HPC, PVP [94] Tablets (Tablet-core-direct compression; body-FDM 3D printing) HPC, EC [59] PLA [81] EVOH, HPMC K15M [65] Tablets (SLS 3D printing) Nylon [82] Cylindrical extrudate (3D printing with simultaneous ionotropic gelation) NA [23] Hydrogel (ionotropic gelation) Graft copolymer of chitosan and PVP [27] Nanofiber (electrospinning) PLA [64] Pellets or cylindrical extrudates (extrusion) Eudragit RSPO, HPMC K15 M, Ethanol PFA [95] Modular gastro-renal delivery system (wet granulation and compression) HPMC K15 M, PEG 6000, PVP K30…”

Section: Air Incorporationmentioning

confidence: 99%

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

Blynskaya

Tishkov²,

Vinogradov³

et al. 2022

Pharmaceutics

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The combination of targeted transport and improvement of the release profile of the active pharmaceutical ingredient (API) is a current trend in the development of oral medicinal products (MP). A well-known way to implement this concept is to obtain floating gastroretentive delivery systems that provide a long stay of the dosage form (DF) on the surface of the stomach contents. The nomenclature of excipients (Es) of a polymeric nature used in the technology of obtaining floating drug delivery systems (FDDS) is discussed. Based on the data presented in research papers, the most widely used groups of polymers, their properties, and their purpose in various technological approaches to achieving buoyancy have been determined. In addition, ways to modify the release of APIs in these systems and the Es used for this are described. The current trends in the use of polymers in the technology of floating dosage forms (FDF) and generalized conclusions about the prospects of this direction are outlined.

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Section: Air Incorporationmentioning

confidence: 99%

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

Blynskaya

Tishkov²,

Vinogradov³

et al. 2022

Pharmaceutics

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Design, development and optimization of itopride hydrochloride loaded floating pellets by spheronization after compression method: In vitro and in vivo evaluation

Dass

Verma

Kaushik

et al. 2023

Preprint

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Background Gastroesophageal reflux disease is the most common disorder with a considerably high global prevalence. It is known to manifest with wide range of symptoms. Prokinetic drugs are commonly recommended in treating gastric reflux in addition to antacids and antisecretory drugs. Itopride, a prokinetic agent, has found to improve symptoms of gastroesophageal reflux disease. It acts as D2 antagonist and acetylcholine esterase inhibitor. Objective This research aimed to develop a gastro retentive system using a dual approach of floating and mucoadhesion.The retention of the formulation was estimated by in vitro floating time and in vivo pharmacokinetic study. Methodology: Different batches of pellets were prepared using ethylcellulose, Eudragit S100 and Carbopol 934 with Itopride hydrochloride by compression and spheronization method. Central composite design (32) was applied to find the effect of independent variables (concentration of Eudragit S100 and ethylcellulose), on dependent variables (floating time and percent drug release). In vivo gastric retention and bioavailability were done on rabbits for optimized pellets formulation. Results All developed formulations passed general evaluations test for pellets (P1-P13). The optimized pellets resulted in the in vitro percent itopride hydrochloride release (97.84%) and (9.3hrs) floating time. In vivo residence was nearly 8hrs and bioavailability was 52.87 ± 0.15 µg/mL/h. Besides, pellets have showed the drug release by sustained action for 12hrs. Conclusion The experimental design of pellets formulation concluded that mucoadhesion with floating approach was suitable for gastric retention and sustained the release of the drug. So, this approach might be useful in controlling the reflux of stomachal fluid.

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Exploring Innovative Approaches in Type-2 Diabetes Management: A Comprehensive Review on Nano-carriers and Transdermal Drug Delivery

Chauhan,

Kumar,

Kumar

et al. 2024

CPD

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Abstract:: Diabetes is a chronic metabolic disorder characterized by elevated blood sugar levels and encompasses various types like type 1, type 2, gestational, and prediabetes. This review delves into the intricacies of type-2 diabetes mellitus and its ideal management. Presently, a spectrum of herbal and synthetic drugs is employed for type-2 diabetes mellitus management. We gathered information about diabetes mellitus from articles published up to 2024 and listed in PubMed, Web of Science, Elsevier, Google Scholar, and similar databases. The keywords used in our search included “diabetes”, “herbal drugs”, “nano-carriers”, “transdermal drug delivery”, etc. By carefully analyzing the research on type-2 diabetes-mellitus, it was found that there is an increase in diabetes-based research, which can be demonstrated by contemplating the PubMed search engine results using transdermal delivery for type-2 diabetes-mellitus as a keyword. The oral consumption of these drugs is associated with numerous side effects, including obesity, pancreatic cancer, and hormonal imbalances. To surmount these challenges, the utilization of nano-carriers and transdermal drug delivery systems emerges as a promising avenue aiming to enhance the therapeutic efficacy of drugs. Nano-carriers represent a revolutionary approach, integrating cutting-edge technologies, inventive strategies, and methodologies to deliver active molecules in concentrations that are both safe and effective, thereby eliciting the desired pharmacological response. This review critically examines the constraints associated with traditional oral administration of anti-diabetic drugs and underscores the manifold initiatives undertaken to revolutionize drug delivery. This review focuses on the limitations associated with the conventional oral administration of anti-diabetic drugs and the many initiatives made so far for the effective and safe delivery of drugs using innovative constituents and techniques.

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Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide

Cited by 6 publications

References 8 publications

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

Design, development and optimization of itopride hydrochloride loaded floating pellets by spheronization after compression method: In vitro and in vivo evaluation

Exploring Innovative Approaches in Type-2 Diabetes Management: A Comprehensive Review on Nano-carriers and Transdermal Drug Delivery

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