2-Tosylacetonitrile (1) when reacted with α,β-unsaturated nitriles 2a-c or a mixture of formaldehyde and 3-amino-2-substituted-pent-2-endinitriles 6a,b yielded pyridine derivatives 3a-c and 9a,b, respectively, while when subjected to react with salicylaldehyde yielded chromene derivatives 4 and 5, subsequently. The behavior of thiocarbamoyl derivative 10 derived from 1 towards some α-halogenated compounds have been investigated as well as its behavior towards elemental sulfur and phenyl isothiocyanate. Newly synthesized compounds were screened for their antioxidant activity, erythrocytes haemolysis and bleomycin-independent DNA damage. Some of the tested compounds exhibited promising activities.
in Wiley Online Library (wileyonlinelibrary.com).One-pot condensation of malononitrile 1, furan-2-carbaldehyde 2, butan-2-one 3, and ammonium acetate in ethanol, followed by cyanoacetylation of the formed nicotinonitrile 4 with 3-(3,5-dimethyl-1H-pyrazol-1yl)-3-oxopropanenitrile 5 afforded the cyanoacetamide 6. Compound 6 was used as a key intermediate for synthesis of nicotinonitriles via reaction with different reagents.
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