Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrobenzothiophene moiety

Crystal structure of 2-phenyl-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d][1,3]oxazin-4-one, C16H13NO2S

“…Tetrahydrobenzothiophene derivatives have many biological activities, such as antivirus, antibacterial, insecticides, acaricides, and antifungal [2,3] as well as anticancer, antitumor, antihistaminic and anti-in ammatory activities [4][5][6][7][8][9][10][11][12][13][14]. Furthermore, tetrahydrobenzothiophene derivatives were reported to inhibit hepatitis C virus NS5B polymerase [15].…”

Synthesis, Characterization, and Antifungal Activity Evaluation of Some Novel Arylazothiazoles

“…The IR spectra were measured on a Pye-Unicam SP300 instrument in potassium bromide discs. The 1 HNMR spectra were recorded on a Varian Mercury VXR-300 spectrometer (300 MHz) using TMS as an internal standard in dimethyl sulfoxide (DMSO)-d 6 . The mass spectra were recorded on a GCMSQ1000-EX Shimadzu and GCMS 5988-A HP spectrometers, and the ionizing voltage was 70 eV.…”

“…One of the most important heterocyclic compounds is thiazole ring because of the wide range of biological activities [1][2][3][4][5][6][7]. Several marketing drugs for several diseases contain thiazole moiety such as sulfathiazole (antimicrobial drug), thiabenzadole (antifungal drug), ritonavir (antiretroviral), cefdinir (bacteriocidal antibiotic of the cephalosporin class of antibiotics), talipexole (treatment for Parkinson's disease), epothilones (cancer drugs), and simeprevir (a drug for the treatment and cure of hepatitis C) (Fig.…”

Synthesis, Biological Activity and Cytotoxicity of New Fused Pyrazolo[1,5-<i>a</i>]pyrimidine from 5-Aminopyrazole Incorporated with <i>p</i>-Chloroaniline

“…Several derivatives such as 4-hydroxypyrazolopyrimidine (allopurin), which are used in the treatment of hyperuricemia and gout, inhibit de novo purine biosynthesis and xanthine oxidase [8]. Cyclization of 5-aminopyrazoles with ketene-S,S and N,S-acetals is the most widely used route for the synthesis of pyrazolopyrimidines [9][10][11][12]. Accordingly, we report in this paper novel synthesis of functionalized pyrazolo [1, 5-a] pyrimidines 4a-b, 5a-c, 6 by the reactions of 5-aminopyrazole 3 with respective 2-[bis (methylthio)methylene]malononitrile 1, ethyl 2-cyano-3,3-bis[methylthio]acrylate, α, α-dicyanoketene-N, S-acetals 2a-c.…”