Synthesis, antitumor and antioxidant evaluation of some new thiazole and thiophene derivatives incorporated coumarin moiety

Gouda, Moustafa A.; Berghot, M. A.; Baz, Eman A.; Hamama, Wafaa S.

doi:10.1007/s00044-011-9610-8

Cited by 67 publications

(33 citation statements)

References 24 publications

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“…Considering the facts that nearly all of the classes of heterocyclic compounds are biologically active and as a part of our continuous efforts towards the development of more potent antioxidant agents [16][17][18][19][20]. It was thought of interest to combine the above mentioned boilable rings together in a molecular framework to investigate the additive effect of these rings towards antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety

et al. 2014

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“…Cyclocondensation of compound 3 with 2-hydroxy-1-naphthaldehyde (29) in boiling ethanol containing a catalytic amount of piperidine afforded corresponding derivative 2-iminocoumarin (30) in high yield (Scheme 5). IR spectrum of the reaction product (30) revealed the disappearance of cyano absorption band and showed absorption bands at 3289, 1682, and 1623 cm À1 corresponding to NH, carbonyl, and C¼N functions, respectively.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antioxidant Evaluation of Some Novel Thiophene, Pyrazole, Chromene, Pyrazolotriazine Derivatives Bearing Sulfonamide Moiety

Gouda

2015

Journal of Heterocyclic Chem

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As a part of ongoing studies in developing new potent antioxidant agents, N‐[4‐(aminosulfonyl)phenyl]‐2‐cyanoacetamide (3) was utilized as key intermediate for the synthesis of some new thiophene, chromene, and pyrazolotriazine pyridine derivatives. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1H‐NMR, and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antioxidant. Compounds 7 and 30 are promising compounds.

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“…Where, stirring of aminopyrazole (11) with an equimolar amount of phenyl isothiocyanate in dimethyl formamide in the presence of potassium hydroxide gave pyrazolo [3,4-d]pyrimidine derivative (24). The IR spectrum of (24) displayed absorption bands at 3457, 3393, 3324, 1660, and 1220 cm À1 because of three NH, cyclic C¼O and C¼S functions; respectively.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Thiazolinone, Aminopyrazole, Pyrazolopyrimidine, and Pyrazolotriazine Derivatives Starting from 1‐Naphthyl‐2‐Cyanoacetamide

Fadda

Rabie

Etman

2016

Journal of Heterocyclic Chem

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Efficient and suitable methods for the synthesis of novel class of simple and fused heterocyclic compounds were prepared starting with 1-naphthyl-2-cyanoacetamide and commercially available reagents. The cyclocondensation of 1-naphthyl-2-cyanoacetamide with sulfanylacetic acid furnished phenylthiazolinone derivative. Stirring of the starting compound with PhNCS afforded thiocarbamoyl derivative which underwent heterocyclization with chloroacetyl chloride to give thiazolinone derivative. 5-Aminopyrazole derivative was prepared by following mild procedures via refluxing the last thiocarbamoyl with hydrazine hydrate. Different synthetic approaches were discussed to obtain the novel fused pyrazolo[1,5-a]pyrimidine, 4H-pyrazolo[3,4-d]pyrimidin-4-one moieties involving the reaction of the prepared 5-aminopyrazole with a) 1, 3-dielectrophilic centers (acetylacetone, acetoacetanilide), b) arylidines of malononitrile, and c) isothiocyanate derivatives. The action of iced sodium nitrite solution in acidic medium on the last 5-aminopyrazole gave pyrazolo [3,4-d][1,2,3]triazine. All novel structure were elucidated by different spectroscopic data (IR, MS,

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Synthesis, antitumor and antioxidant evaluation of some new thiazole and thiophene derivatives incorporated coumarin moiety

Cited by 67 publications

References 24 publications

Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety

Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety

Synthesis and Antioxidant Evaluation of Some Novel Thiophene, Pyrazole, Chromene, Pyrazolotriazine Derivatives Bearing Sulfonamide Moiety

Synthesis of Thiazolinone, Aminopyrazole, Pyrazolopyrimidine, and Pyrazolotriazine Derivatives Starting from 1‐Naphthyl‐2‐Cyanoacetamide

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