Also, patients in the younger age group had bigger spleens as compared to old (65% vs. 42%). 11 patients also had significant lymphadenopathy, most commonly involving the inguinal group. Hemoglobin (Hb) level was in the range of 5.5-13.0 g/dl (9.4 ± 4.8). Mean Hb levels did not differ much among the three phases [Table 2]. Average platelet count in younger group was significantly higher than in the older age group (mean 3.63 × 10 5 / µl ± 1.99 vs. 2.62 × 10 5 /µl ± 1.40; P = 0.01) [Table 2]. Available data suggest that the epidemiology of CML is different in the Indian subcontinent and in other developing countries from that of the rest of the world. [3] In our study, the median age was 35 years (range 11-70 years) which is significantly lower than reported in European [4] (median age 55 years) and American literature [5] (median age 66 years). In the study by Bhutani et al., the median age of onset is 38 years in India [2] while in a regional study in Pakistan mean age was 37.87 years which is quite less than the age of presentation in west. [6] Shorter life expectancy, Table 2: Peripheral blood findings in patients according to phases Value CP (n=39) AP (n=10) BC (n=19) Hb (g/dl) range 5.5-13.0
The parotid gland tumors are classified according to their morphological and histological patterns. The most common site of presentation of a salivary neoplasm is the parotid gland. Sclerosing polycystic adenosis (SPA) is a rare disease of the salivary glands, first described by Smith et al at 1996. We report a case of 61 year gentleman admitted in KVG Medical college and hospital with complains of swelling in right side of face since 6 months. Local examination of right parotid region showed solitary swelling with ipsilateral mandibular lymphadenopathy. EBV profile was positive. CT head and neck revealed an enlarged right sided parotid gland resembling features of Pleomorphic adenoma. Fine needle aspiration of gland showed features of chronic sialo-adenitis. A provisional diagnosis of Pleomorphic Adenoma was made. Patient underwent superficial parotidectomy. Histopathology of the operated specimen had features suggestive of Sclerosing polycystic adenosis of parotid gland. Patient was followed up for a period of one year and he had no recurrence. To conclude, Sclerosing polycystic adenosis of the parotid gland is a rare benign salivary gland lesion with histologic analogies to sclerosing adenosis of the mammary gland. Complete surgical excision is the reference treatment, to reduce the risk of recurrence and/or evolution.
Background: Diabetic foot ulcer is a serious and common complication of diabetes mellitus. 12%–25% have a risk of developing a foot ulcer during their lifetime. Diabetic neuropathy and micro- or macro-ischemia are the two main risk factors that cause diabetic foot ulcer.Methods: A cross sectional study was conducted in dept of general surgery, KVGMCH between 1st November 2019 and 30th August 2020 among 90 pts with diabetic foot ulcers, selected by systematic random sampling methods. Considering prevalence of DFU, among the diabetic pts as 8.8%, the sample size was estimated to be 90 using the formula 4pq/L2, with absolute error as 6%. Patients will be managed conservatively with antibiotics like aminoglycosides, cephalosporins, penicillin derivatives and dressings and if needed surgical interventions will be performed.Results: Maximum number of pts had HbA1c levels of >8% and they accounted for 35.55%. Almost 98% of the patients had neuropathy, 50% of them had signs of ischemia and 80% had infection. Maximum number of patients (58.88%) presented with diabetic ulcers belonging to Class 2 of Wagners classification. The most commonly isolated P. aeruginosa was sensitive to colistin, imipenem and amikacin. Most diabetics with HbA1C levels >8, had mean antibiotic duration of 19.04±4.65 days.Conclusions: Prevention is the best treatment. Wagner’s classification helps in correlating appropriate treatment to proper grade of lesion with better outcome. Effective glycemic control and education are of key importance for decreasing diabetic foot disease.
Introduction: TNBC is associated with high mortality, morbidity and low survival rates. This study is aimed to study difference in pathological characteristics, disease free survival and recurrence between TNBC and Non-TNBC. Materials and Methods: Total 208 patients, who are diagnosed cases of breast carcinoma visiting our out patient department between August 2020 and July 2022 were enrolled. Demographic details, details during the presentation, pathological characterstics including the HPE, grade and receptor status, modality of treatment were taken. Enrolled patients were followed up. At the end of the study period, 2 year disease free survival, overall survival, recurrence of malignancy were noted. 102 patients who lost followup, status unknown or who has not completed a period of 2 years after diagnosis of Breast carcinoma were excluded. 106 patients were nalised, details were entered in excel sheet. Patients were divided into TNBC and Non-TNBC group and compared. Results: Prevalence of TNBC in our study was 22.6. Tumor size is more at presentation in TNBC compared to Non TNBC. All patients with TNBC had positive nodes during presentation (100%Vs78%). Presence of metastasis at the time of diagnosis is more in TNBC group(20.8%Vs 8.5%). Both groups has Intraductal Carcinoma as the predominant variant. Most of the TNBC had poorly differentiated grade tumors when compared to Non-TNBC. TNBC has more local(38.8% Vs 18.7%) and metastatic(22.22% Vs 4%) recurrences. 2 year Diseases free survival was more in Non-TNBC group(77.33% Vs 38.88%). Conclusions: TNBC has overall lesser disease survival period, more local and metastatic recurrences. Stage at diagnosis in TNBC is more advanced. Hence TNBC has got poor prognosis and high mortality. Early diagnosis and treatment is the key in reducing the mortality and better prognosis.
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