Since roentgen rays were first applied to therapeutic uses two decades ago, studies and experimentation have resulted in the development of two widely separated schools concerning their method of application. Briefly, the older method is that by which maximum effects are gradually obtained by the administration of small doses, repeated at short intervals, and continued over a long period of time. This method has long been known as that of "fractional dosage," and the results obtained by it, in the hands of Pusey and others, have deservedly commanded the respect of the profession. Differing radically from the preceding is the more recent method of "massive dosage," by which MacKee and others have obtained results favorably comparable to those of the older method. By this procedure the maximum effect is obtained at once, and the dose is not repeated for an extended time. In spite of this wide divergence in methods, to the results obtained by each is due the respected position which roentgen
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