NUTRITIONAL REQUIREMENTS OF THE PATHOGENIC MOLD <i>TRICHOPHYTON INTERDIGITALE</i>

Mosher, William A.; Saunders, Donald Herbert; Kingery, Lyle B.; Williams, Roger J.

doi:10.1104/pp.11.4.795

Cited by 67 publications

(13 citation statements)

References 7 publications

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“…[172223] Unsaturated transferrin inhibits the growth of dermatophytes by binding to the hyphae. [24] A growth modifying, α 2 macroglobulin keratin inhibitor, has also been identified in serum.…”

Section: Penetrationmentioning

confidence: 99%

Pathogenesis of dermatophytoses

Tainwala

2011

Indian J Dermatol

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Dermatophytes can survive solely on outer cornified layers of the skin. The ability of certain fungi to adhere to particular host arises from numerous mechanisms and host factors, including the ability to adapt to the human body. Natural infection is acquired by the deposition of viable arthrospores or hyphae on the surface of the susceptible individual. After the inoculation in the host skin, suitable conditions favor the infection to progress through the stages of adherence and penetration. Development of host response is mostly by a T-cell mediated response of delayed-type hypersensitivity. Antibody formation does not seem to be protective. Natural defenses against dermatophytes depend on both immunological and nonimmunological mechanisms.

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Section: Penetrationmentioning

confidence: 99%

Pathogenesis of dermatophytoses

Tainwala

2011

Indian J Dermatol

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“…Sucrose is utilized slightly but definitely by M . canis (Giblett & Henry, 1950; Goddard, 1934) and by Trichophyton interdigitale (Goddard, 1934; Mosher, Saunders, Kingery & Williams, 1936). Mosher et al (1936) used sucrose as the carbon source in their basal medium.…”

Section: P H Y L L I S M S T O C K D a L Ementioning

confidence: 99%

Nutritional Requirements of the Dermatophytes

Stockdale

1953

Biological Reviews

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“…Leucine was found to be nearly indispensable for T . interdigitale (Mosher et al 1936), and leucine and glycine were included by Robbins & Ma (1945) among the acids which gave best growth of T . mentugrophytes.…”

Section: P M Stockdalementioning

confidence: 99%

Requirements for the Growth and Sporulation of Trichophyton persicolor

Stockdale¹

1953

Journal of General Microbiology

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SUMMARY: The optimum temperature for the growth and sporulation of Trichophyton ~U S~C O Z O T was 25-30' ; 4 0 ' inhibited growth. A range of pH values from 4 to 10 was compatible with growth, the optimum pH value being slightly less than pH 7. Macroconidia were produced over a narrower range and were most abundant at pH 8.Percentage germination and length of germ tube were greatest at 100 yo humidity. No germination occurred at humidities of below about 95 yo. Exposure to light had no effect on growth rate, sporulation or pigmentation.The carbon compounds which supported best growth were mannose, glucose, mannitol and maltose. Nitrates were not utilized, and ammonium sulphate, urea and asparagin supported poor growth. The amino-acids leucine, glycine, histidine and cysteine were utilized; with all other single amino-acids tested, growth was negligible. Methionine and phenylalanine were inhibitory.T . persicolor was autotrophic for vitamins. It grew as well on a vitamin-free medium as on the basal medium.The elements zinc, iron, copper and manganese, as sulphates, stimulated the growth and sporulation of T . persicolor on a medium treated for the removal of trace elements.This investigation arose from an observation that two isolates of Trichophyton persicolor (M2, isolated in France, and M3, isolated in Britain) grew yery differently from each other on Sabouraud's ' conservation ' medium in which a peptic digest of meat replaced commercial peptone, while on Sabouraud's maltose ' proof' medium containing the same digest as nitrogen source their cultural appearance was similar. As no detailed investigation of the physiology of T . persicolor had been made previously it was decided to make a study of the nutritional and physico-chemical growth requirements of M2 and Ma. Other isolates of T . persicolor were frequently included for comparison. Among these were one (M 323) from Dr R. Vanbreuseghem (Institut de Mddecine Tropicale Prince-Ldopold, Anvers), four (M 330, M332, Ma38 and M335) from Dr Jacqueline Walker (London School of Hygiene and Tropical Medicine) and two (S45 and S78) recently isolated from material sent to this laboratory.No explanation of the difference between M2 and M 3 has emerged during the course of this work, but an outstanding effect of environmental conditions of the production of macroconidia has been frequently noted.

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NUTRITIONAL REQUIREMENTS OF THE PATHOGENIC MOLD TRICHOPHYTON INTERDIGITALE

Cited by 67 publications

References 7 publications

Pathogenesis of dermatophytoses

Pathogenesis of dermatophytoses

Nutritional Requirements of the Dermatophytes

Requirements for the Growth and Sporulation of Trichophyton persicolor

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