Background/Aims: Several studies have been performed to unravel the association between diabetes and increased susceptibility to infection. This study aimed to investigate the effect of insulin on the local environment after cecal ligation and puncture (CLP) in rats. Methods: Diabetic (alloxan, 42 mg/kg i.v., 10 days) and non-diabetic (control) male Wistar rats were subjected to a two-puncture CLP procedure and 6 h later, the following analyses were performed: (a) total and differential cell counts in peritoneal lavage (PeL) and bronchoalveolar lavage (BAL) fluids; (b) quantification of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10 and cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in the PeL and BAL fluids by enzyme-linked immunosorbent assay (ELISA); (c) total leukocyte count using a veterinary hematology analyzer and differential leukocyte counts on stained slides; (d) biochemical parameters (urea, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) by colorimetric analyses); and (e) lung, kidney, and liver morphological analyses (hematoxylin and eosin staining). Results: Relative to controls, non-diabetic and diabetic CLP rats exhibited an increased in the concentration of IL-1β, IL-6, IL-10, CINC-1, and CINC-2 and total and neutrophil in the PeL fluid. Treatment of these animals with neutral protamine Hagedorn insulin (NPH, 1IU and 4IU, respectively, s.c.), 2 hours before CLP procedure, induced an increase on these cells in the PeL fluid but it did not change cytokine levels. The levels of ALT, AST, ALP, and urea were higher in diabetic CLP rats than in non-diabetic CLP rats. ALP levels were higher in diabetic sham rats than in non-diabetic sham rats. Treatment of diabetic rats with insulin completely restored ALT, AST, and ALP levels. Conclusion: These results together suggest that insulin attenuates liver dysfunction during early two-puncture CLP-induced peritoneal inflammation in diabetic rats.

The prevalence of cholesteatoma in patients with chronic otitis media was 24.5% and it was more common in adults than in children. Posterior mesotympanic cholesteatoma was more frequent, with no difference in mean air-bone gap between the different routes of formation. In patients undergoing surgery, open tympanomastoidectomy was the procedure most frequently chosen.

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The high mortality rate found may reflect the high complexity of the institution's patients. Knowing the profile of the patients assisted helps in the definition of management priorities, suggesting the need to create specific care lines for groups identified as high risk in order to reduce perioperative complications and deaths.

Poster Presentations P197Under general anaesthesia, the patient was positioned supine, with the head turned away from the site of the BBI. Local anaesthetic was administered and a postauricular incision was made and deepened down to bone. The subperiosteal flap was elevated and the surgeon determined the location of the FMT, with the help of the IGL. A conservative cortical mastoidectomy was performed to create a well for the FMT to sit in. A subperiosteal pocket for the receiver coil was created posterior-superior to the well.Results: Five patients underwent BBI surgery with IGL. Rapid and accurate localization of the site of the well for the FMT was possible in each case.Conclusions: The authors recommend IGL as a safe, rapid, and reproducible technique in localization of the site for the well of the BBI. Can Routine Office-Based Audiometry

Objectives: Analyze the difference in acufenometry between patients with presbycusis and Ménière's disease and correlate the findings with the annoyance caused by tinnitus.Methods: This cross-sectional study included 59 patients with unilateral tinnitus treated at a tertiary hospital. Out of these patients, 38 had presbycusis and 21 had Ménière's disease. Acufenometry was performed to determine the pitch and loudness of tinnitus in the 2 groups. The tinnitus handicap inventory (THI) and visual analogue scale (VAS) was used to evaluate the annoyance caused due to tinnitus. Statistical analysis was performed using SPSS and the Student t test.Results: The mean age of the patients with Ménière's disease and presbycusis was 56.05 ± 8.73 years and 67.74 ± 8.73 years, respectively (P < .0001). Similar tinnitus pitch was observed in patients with Ménière's disease and those with presbycusis (2119 ± 2000 Hz vs 3092 ± 2203 Hz; P = .09); however, the loudness varied between the groups (61.19 ± 17.2 dB vs 42.17 ± 19.8 dB; P = .001). The THI and VAS score were similar between the two groups (P = .33 vs P = .66).

Instituição: FACIPLAC O tumor de Frantz foi caracterizado pela primeira vez em 1959 pela médica Virgínia Frantz. É uma neoplasia rara do pâncreas que acomete, em sua maioria, mulheres jovens. Tem manifestações clínicas inespecíficas, em geral, possui prognóstico positivo após tratamento cirúrgico com ressecção completa do tumor. Os exames de imagem são importantes na suspeita diagnóstica mas somente o exame histopatológico confirma o tumor sólido pseudopapilar do pâncreas. Este relato de caso é de uma paciente de 32 anos de idade com quadro de dor abdominal isoladamente apresentando tumor de Frantz na cabeça do pâncreas como diagnóstico definitivo. Foi tratada com duodenopancreotectomia -Cirurgia de Whipple e mais duas cirurgias de reparação para gastroparesia. A paciente possui acompanhamento de 5 anos onde apresentou diversas complicações como esteatorréia, insuficiência pancreática exócrina e anemia megaloblástica. O seguimento clínico por 5 anos não mostrou recidiva tumoral. O caso relatado foi selecionado por apresentar um quadro clínico atípico de tumor pancreático, tendo como diagnóstico uma neoplasia rara -Tumor de Frantz com acompanhamento de 5 anos. Além das complicações pós cirúrgicas não habituais e pouco relatas na literatura. ABCDExpress 2017;1(2):475Codigo: 60934 Acesso está disponível em www.revistaabcd.com.br e www.sbad2017.com.br Acesso pelo

Presentation schedule is subject to change. For the most up-to-date information, visit www.entannualmeeting.org. Objectives: Although most of the laryngeal leukoplakias are temporal inflammatory lesions in non-smokers, some patients represent serious histopathologies to require careful management. The purpose of this study was to clarify unique clinical features of the patients who require cautious care in this lowrisk group.Methods: One hundred fifty-four consecutive patients referred to our institution with laryngeal leukoplakia from June 2006 to May 2013. Of these, 24 patients without smoking history were incorporated in this study. Retrospective chart reviews and the re-evaluations of video-taped laryngeal images were performed. Sequential change of vocal quality (Grade, Roughness, Breathiness, Asthenia, Strain scale) was assessed in each patient. Timings to show improvements of laryngeal images were studied in the patients with spontaneous disappearances of leukoplakias (n = 12). Furthermore, excisional biopsies were performed on 12 patients and their histopathologies and vocal/stroboscopic characteristics were compared with each other.Results: Spontaneous disappearances of the lesions were observed 4.6 months after referral to our hospital on average, and these patients presented vocal quality of G1 or G0 at their first visits. Additionally, gradual recoveries in their glottal closure and/or pliability of diseased vocal folds were observed in this group. Furthermore, patients with histopathology of severe dysplasia/cancer presented with either (1) no improvement in their G2 voice for 1 month, (2) incomplete glottal closure coupled with abnormal pliability of diseased vocal folds for 1 month, or (3) abnormal pliability of diseased vocal folds for 4 months.Conclusions: Our analyses identified several specific findings to predict serious pathology in laryngeal leukoplakia patients without smoking history.