Toxic epidermal necrolysis is a rare, severe cutaneous reaction, mostly caused by drugs. It affects the skin and mucous membranes, with involvement of more than 30% of body surface. We describe the case of a young woman, previously healthy, who developed skin detachment of more than 90% of the body surface 15 days after being administered lansoprazole for peptic disease. The treatment consisted in discontinuation of the drug involved and early administration of intravenous human immunoglobulin, which led to a satisfactory outcome of the case, substantiating the impact of early diagnosis and treatment on the morbidity and mortality of these patients.
Vascular leiomyoma are uncommon benign smooth muscle tumors which generally present as a single painful nodule in the lower limbs. We report a case of vascular leiomyoma on the second finger of the left hand, an unusual location for this tumor.
Verrucous epidermal nevi are congenital hamartomas composed of keratinocytes and may
occur alone or in association with developmental abnormalities. A close relationship
between variations in the PIK3CA and FGFR3 genes and the appearance of nevi has been
recently reported. Based on that, we performed molecular assays for the
identification of E542K, E545G/K and H1047R mutations in the PIK3CA gene and of the
R248C mutation in the FGFR3 gene. Interestingly, during the amplification process, we
did not observe the PCR product of exon 9 of the PIK3CA gene, a region comprising
amino acids 542-545. This strongly suggests the occurrence of a microdeletion of that
region and indicates a possible allelic variant, which has not yet being described in
the literature.
The millipedes (also known as "gongolos") are arthropods characterized by a cylindrical body consisting of rings. When threatened, they release chemicals that can cause erythema and hyperpigmentation. We report the case of a patient who developed a darkened macule on the plantar region after stepping on a millipede. Dermatoscopic examination showed a parallel-ridge pattern, which is considered typical for acral melanoma. A detailed history was essential for the diagnosis, as the clinical and dermatoscopic features suggested a malignant melanocytic lesion.
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