“…However, in rare cases, skin tumors, such as squamous cell carcinomas, basal cell carcinomas, and poroid cell neoplasms, can arise within the lesion . To date, several somatic gene mutations, such as FGFR3 , PIK3CA , and HRAS , have been identified in EN . Herein, we describe a case of seborrheic keratosis (SK) arising on an area affected by EN with the HRAS p.G13R mutation that was identified by next‐generation sequencing (NGS).…”