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We report a case of verrucous carcinoma of the bladder that was unrelated to bilharziasis, with koilocytosis and absence of human papillomavirus. The literature relating to the topic is discussed.

IntroductionMetabolic syndrome (MS) comprises several metabolic disorders that are risk factors for cardiovascular disease and has its source connected to the accumulation of visceral adipose tissue (VAT) and development of insulin resistance. Despite studies showing beneficial results of exercise on several risk factors for cardiovascular disease, studies evaluating the effects of different intensities of exercise training on the pancreas with experimental models are scarce.MethodsIn total, 20 Wistar rats were used, divided into four groups: control (C), metabolic syndrome (MS and without exercise), metabolic syndrome and practice of walking (MSWalk), and metabolic syndrome and practice of running (MSRun). The applied procedures were induction of MS by fructose in drinking water; experimental protocol of walking and running; weighing of body mass and VAT; sacrifice of animals with blood collection and removal of organs and processing of samples for light microscopy using the analysis of volume densities (Vv) of the studied structures.ResultsRunning showed a reduction of VAT weight (−54%), triglyceride levels (−40%), Vv[islet] (−62%), Vv[islet.cells] (−22%), Vv[islet.insterstitial] (−44%), and Vv[acinar.insterstitial] (−24%) and an increase of Vv[acini] (+21%) and Vv[acinar.cells] (+22%). Regarding walking, we observed a decrease of VAT weight (−34%) and triglyceride levels (−27%), an increase of Vv[islet.cells] (+72%) and Vv[acinar.cells] (+7%), and a decrease of Vv[acini] (−4%) and Vv[acinar.insterstitial] (−16%) when compared with those in the MS group.ConclusionOur results suggest that the experimental model with low-intensity exercise (walking) seems to be more particularly recommended for preventing morphological and metabolic disorders occurring in the MS.

BackgroundChronic chagasic heart disease represents extensive remodeling of the cardiovascular system, manifested as cardiac denervation, interstitial mononuclear infiltrate, myocyte and vascular degenerative changes, fibrosis, and hypertrophy. Moreover, aerobic exercises are widely indicated for the treatment of various disorders of the cardiovascular system.PurposeTo evaluate the right and left ventricles of BALB/c mice with chronic Chagas disease, undergoing mild exercise, by using morphometric and stereological methods.Materials and methodsA total of 20 male mice at 4 months of age were used for experiments. The animals were divided into four groups (n=5 in each group): untrained control, trained control, untrained infected (UI), and trained infected (TI). Animals of UI and TI groups were inoculated with 1,000 trypomastigote forms of Trypanosoma cruzi (Y strain), and after 40 days, animals entered chronic phase of the disease. Physical exercise, which included swimming, was performed for 30 minutes daily, five times a week for 8 consecutive weeks at a bath temperature of 30°C. After the trial period, euthanasia and subsequent withdrawal of the heart were done. The organ was prepared by histological staining procedures with hematoxylin–eosin and picrosirius red.ResultsWe found that the physical training used in our experimental model promoted increase in volume density of capillaries and decrease in volume density of collagen fibers and cross-sectional area of cardiomyocytes in chagasic animals (TI group). By histopathological analysis, we found differences in the inflammatory infiltrate, which was lower in animals of TI group. The training program promoted a recovery of these parameters in the TI group.ConclusionOur results suggest that low-intensity aerobic exercise acts on morphological and morphometric parameters of the left and right ventricles in mice infected with T. cruzi, reducing the changes caused by the organism and making the results comparable to those of the uninfected control group.

Introdução A endometriose é uma doença multifocal caracterizada pelo crescimento anormal de tecido endometrial fora da cavidade uterina, de progressão rápida e imprevisível. Os principais sítios de lesão são os ovários, ligamentos útero-sacros e redondo e fundo de saco de Douglas. A patogênese desta afecção é desconhecida, mas algumas teorias têm sido propostas. Estas incluem a menstruação retrógrada, disseminação do tecido endometrial durante cirurgia, remanescentes embrionários, metaplasias, metástases linfáticas e hematogênicas 1,2 . O acometimento do trato urinário é raro e ocorre em 1-2% dos casos, sendo a bexiga acometida em 80% das vezes. O primeiro caso de endometriose vesical foi descrito em 1921 1,2 . Em 1960, revisando 6.107 casos de endometriose dentro de grandes séries desde 1925, Abeshouse e Abeshouse 3 encontraram apenas 67 casos de endometriose vesical, que correspondia a apenas 1,1% dos possíveis sítios de instalação desta patologia. Nessa extensa revisão, foram descritos 6 casos de endometriose renal (0,1%), 15 de acometimento ureteral (0,24%) e 3 em topografia uretral (0,05%). O quadro clínico é variado, podendo apresentar-se como hematúria cíclica, dor pélvica e sintomas vesicais irritativos. Os principais diagnósticos diferenciais incluem angiomas, papilomas, lesões inflamatórias inespecíficas como a cistite eosinofílica, cistite intersticial e a cistite cística, malacoplaquia, tuberculose e carcinoma vesical [1][2][3][4][5] . O diagnóstico preciso é necessário para instituirmos a terapêutica apropriada.

Methods: Experimental phase: Performed a partial nephrectomy off clamp in pig model followed by cauterization of lidocaine gel 2% with different power (control, 30W, 50W and 100W) in the kidney resection bed to evaluate efficacy and deep injury extension. Clinical phase: 20 patients submitted to laparoscopic or partial nephrectomy for low risk RENAL score were utilized greased lidocaine gel 2% with 50W in cautery scalpel to hemostasis of renal parenchima to validate efficacy and safety. Results: Experimental study shows that this technique is effective and promote better hemostasis with 50W and 100W, with deep injury of less than 3 mm. Clinical study confirm efficacy, good control of hemorrage, few complications and no transfusion. Minimal changes in hematocrit, haemoglobin and creatinine were observed. Conclusion: In this preliminary experience the use of this new alternative to hemostasis for low risk partial nephrectomy was satisfactory and with good intra and postoperative results. The best advantages were safety in terms of the depth thermal injury, low cost and absence of artifacts over the resection area observed at CT scan postoperatively.

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