Influence of asymptomatic histologic prostatitis on serum prostate-specific antigen: A prospective study

Simardi, Lucíla Heloísa; Tobias-Machado, Marcos; Kappáz, Guilherme Tommasi; Goldenstein, Patricia Taschner; Potts, Jeannette M.; Wroclawski, Eric Roger

doi:10.1016/j.urology.2004.08.060

Cited by 51 publications

(31 citation statements)

References 16 publications

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“…Our findings are in accord with those of Simardi et al [16] . Similar results have been reported by Yaman et al [17] , who related the PSA elevation to the extent of inflammation within the prostate tissue.…”

Section: Discussionsupporting

confidence: 94%

Serum Prostate-Specific Antigen Levels in Middle Eastern Men with Subclinical Prostatitis

et al. 2006

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Objective: To investigate the influence of subclinical or histologically diagnosed prostatitis on serum prostate-specific antigen (PSA) in patients investigated for prostatic disease in Kuwait. Materials and Methods: Serum PSA was assayed in patients investigated for prostatic disease in Mubarak Al-Kabeer Hospital, Kuwait, between December 2002 and December 2004. These included patients undergoing transrectal ultrasound with needle biopsy of the prostate gland and those who were treated with transurethral resection of the prostate or retropubic prostatectomy. The tissue was evaluated for prostatitis as well as the underlying disease, and the type and severity of prostatitis were compared with levels of serum PSA. Results: Of the 331 tissue specimens, 18 (5.4%) did not show prostatitis, while 233 (70.4%) with benign prostate and 80 (24.2%) with malignant prostate disease showed prostatitis. Of 270 men with known serum PSA levels, 198 and 72 had benign and malignant prostate disease, respectively. Of the 198, 77 (41%) with benign prostate disease and prostatitis and of the 72, 52 (76%) with malignant prostate disease and prostatitis had serum PSA levels >10 ng/ml. Conclusion: The data showed that although raised serum PSA is more commonly associated with prostate cancer, subclinical prostatitis is a significant source of high serum PSA in over 40% of men in Kuwait. That local factors may obscure the usefulness of serum PSA as a screening tool suggests the need for a locally applicable paradigm to identify prostate cancer.

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Section: Discussionsupporting

confidence: 94%

Serum Prostate-Specific Antigen Levels in Middle Eastern Men with Subclinical Prostatitis

et al. 2006

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“…16 Recently a prospective study of 51 patients without evidence of ACP demonstrated extension of the inflammatory process directly related to elevations of serum PSA levels. 17 Correlating with these conclusions, the present data demonstrate a significantly elevated serum PSA in men with BPH plus prostatitis versus BPH alone (504.1 v. 8.8 ng/ml, p>0.001). Approaching significance, serum PSA was also increased in men with ACP plus prostatitis versus ACP alone (1 672 v. 41 ng/ml, p=0.076).…”

Section: Discussionsupporting

confidence: 84%

Prevalence of histological prostatitis in men with benign prostatic hyperplasia or adenocarcinoma of the prostate presenting without urinary retention

Edlin¹,

Heyns²,

Vuuren³

et al. 2012

S Afr J Surg

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Prostatic disease causes enormous morbidity worldwide. Currently adenocarcinoma of the prostate (ACP) is the most common form of cancer in men in the USA, with a predicted cost of US $8.8 billion for continuing care of these patients by 2020.1 Moreover, benign prostatic hyperplasia (BPH) affects an estimated 70% of men aged 61 -70 years and 90% of those aged 81 -90. By 2025, BPH is likely to affect 20% of the total male population.2 Improved understanding of these diseases could have a significant impact on male health. ACP and BPH are chronic diseases with a long period of development and progression. Interestingly, a self-reported history of prostatitis is associated with ACP and BPH. 3 The role of inflammation in prostatic disease is currently yet to be fully elucidated, although there is emerging evidence that prostatic inflammation may contribute to prostate growth in terms of hyperplastic or neoplastic changes. 4 Histological evidence of inflammation has been reported in approximately 40% of cases of BPH and is associated with a significantly increased risk of acute urinary retention.5 About 20% of all human cancers are caused by chronic inflammation, perhaps including ACP. 6 A better understanding of the relationship between prostatic inflammation and BPH or ACP may provide an opportunity to influence the diagnosis or treatment of prostatic disease.In a previous study, we analysed 405 men presenting with urinary retention and found histological evidence of prostatitis in 98/204 men (48.0%) with BPH and in 51/201 (25.4%) with Objective. To determine the prevalence of prostatitis on histopathological evaluation of prostatic tissue in men without urinary retention. Design, setting and subjects. The clinical data and histopathology reports of men seen from January 1999 through March 2009 at our institution were analysed using Student's t-test, the Mann-Whitney test and Fisher's exact test where appropriate. Values were expressed as means, medians and ranges (p<0.05 accepted as statistically significant). Outcome measures. Data collected included patient age, duration of lower urinary tract symptoms and hospitalisation, findings on digital rectal examination, prostate volume, haemoglobin concentration, serum creatinine and prostate-specific antigen (PSA) levels, and histological findings. Results. Prostatic tissue of 385 men without urinary retention at presentation was obtained via biopsy (48.3% of cases), transurethral prostatectomy (62.9%), retropubic prostatectomy (6.8%) or radical prostatectomy (28.3%). On histological examination, benign prostatic hyperplasia (BPH) was found to be present in 213 patients (55.3%) and adenocarcinoma of the prostate (ACP) in 172 (44.7%). Histological prostatitis was present in 130 patients (61.0%) with BPH and 51 (29.7%) with ACP (p<0.001). A previous study of 405 men presenting with urinary retention at our institution showed histological prostatitis in 98/204 (48.0%) with BPH and in 51/201 (25.4%) with ACP. The group of men with BPH alone had a significantly lower mean se...

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“…In the study by Anim et al demonstrated that increasing serum PSA was observed for increasing grades of inactive chronic prostatitis [21]. Similarly, Simardi and associates demonstrated that the extension of the inflammatory process, as evaluated by the number of specimens involved, was directly related to elevations of serum PSA levels in asymptomatic patients [22]. Irani et al [7] graded the extent of inflammation and the aggressiveness of inflammation in patients with elevated PSA who were negative for prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

et al. 2006

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Influence of asymptomatic histologic prostatitis on serum prostate-specific antigen: A prospective study

Cited by 51 publications

References 16 publications

Serum Prostate-Specific Antigen Levels in Middle Eastern Men with Subclinical Prostatitis

Serum Prostate-Specific Antigen Levels in Middle Eastern Men with Subclinical Prostatitis

Prevalence of histological prostatitis in men with benign prostatic hyperplasia or adenocarcinoma of the prostate presenting without urinary retention

The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis

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