Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)-2,9-dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1A, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC(50) values of less than 10 µM, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.
The Chinese lunar probe Chang'E-4 successfully landed in the Von Kármán crater on the far side of the Moon. This paper presents the topographic and geomorphological mapping and their joint analysis for selecting the Chang'E-4 landing site in the Von Kármán
crater. A digital topographic model (<small>DTM</small>) of the Von Kármán crater, with a spatial resolution of 30 m, was generated through the integrated processing of Chang'E-2 images (7 m/pixel) and Lunar Reconnaissance Orbiter (<small>LRO</small>)
Laser Altimeter (<small>LOLA</small>) data. Slope maps were derived from the <small>DTM</small>. Terrain occlusions to both the Sun and the relay satellite were studied. Craters with diameters ≥ 70 m were detected to generate a crater density map. Rocks with diameters
≥ 2 m were also extracted to generate a rock abundance map using an <small>LRO</small> narrow angle camera (<small>NAC</small>) image mosaic. The joint topographic and geomorphological analysis identified three subregions for landing. One of them, recommended as
the highest-priority landing site, was the one in which Chang'E-4 eventually landed. After the successful landing of Chang'E-4, we immediately determined the precise location of the lander by the integrated processing of orbiter, descent and ground images. We also conducted a detailed analysis
around the landing location. The results revealed that the Chang'E-4 lander has excellent visibility to the Sun and relay satellite; the lander is on a slope of about 4.5° towards the southwest, and the rock abundance around the landing location is almost 0. The developed methods and results
can benefit future soft-landing missions to the Moon and other celestial bodies.
Background: Flowering plants (angiosperms) dominate most global ecosystems today, but their rapid Cretaceous diversi cation has remained poorly understood ever since Darwin referred to it as an 'abominable mystery'. Although numerous Cretaceous fossil owers have been discovered in recent years, most are represented by incomplete charcoali ed fragments that do not preserve delicate structures such as complete petals and surface textures, which means that their similarity to living forms is often di cult to discern. The scarcity of information about the ecology of early angiosperms makes it di cult to test hypotheses about the drivers of their diversi cation. Among other factors, frequent res in the Cretaceous have been postulated as having possibly facilitated the rise of angiosperms. However, to date no early fossil angiosperms displaying re-adapted traits have been known, making the role of re in shaping Cretaceous oras uncertain.Results: We report the discovery of two exquisitely preserved fossil ower species, one identical to the in orescences of the extant crown eudicot genus Phylica and the other recovered as a sister group to Phylica, both preserved as inclusions in Cretaceous amber from northern Myanmar (~99 Ma). These specialized ower structures, named Phylica piloburmensis sp. nov. and Eophylica priscastellata gen. et sp. nov., were adapted to surviving frequent wild res, providing the earliest evidence of re-resistance in angiosperms. The fossils suggest that re was a signi cant selective force in Cretaceous angiosperm oras and that adaptations to re resistance in some eudicot clades have been conserved for at least 99 Ma. This morphological stasis encompasses a range of oral characters, including the production of 'pseudo-owers', and characteristic fruit and pollen architecture. Given its morphological distinctiveness,
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