Limestone, a major part of the global sedimentary succession, susceptible to post-depositional diagenesis. Studies of limestone geochemistry are essential in the discrimination of tectonic settings of basins in which the limestones were deposited. Six Late Mesozoic and one Tertiary limestone successions of Tibet, western China, that were deposited in oceanic plateau, passive continental margin, active continental margin (fore-arc basin, back-arc basin and foreland basin) and continental inland freshwater basins were analyzed for their major, trace and rare earth element (REE) composition. This geochemical dataset, in combination with the Deep Sea Drilling

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Icariside II (ICS II) is a broad-spectrum anti-cancer natural compound extracted from Herba Epimedii Maxim. Recently, the role of ICS II has been investigated in central nervous system, especially have a neuroprotective effect in Alzheimer’s disease (AD). In this study, we attempted to investigate the effects of ICS II, on cognitive deficits and beta-amyloid (Aβ) production in APPswe/PS1dE9 (APP/PS1) double transgenic mice. It was found that chronic ICS II administrated not only effectively ameliorated cognitive function deficits, but also inhibited neuronal degeneration and reduced the formation of plaque burden. ICS II significantly suppressed Aβ production via promoting non-amyloidogenic APP cleavage process by up-regulating a disintegrin and metalloproteinase domain 10 (ADAM10) expression, inhibited amyloidogenic APP processing pathway by down-regulating amyloid precursor protein (APP) and β-site amyloid precursor protein cleavage enzyme 1 (BACE1) expression in APP/PS1 transgenic mice. Meanwhile, ICS II attenuated peroxisome proliferator-activated receptor-γ (PPARγ) degradation as well as inhibition of eukaryotic initiation factor α phosphorylation (p-eIF2α) and PKR endoplasmic reticulum regulating kinase phosphorylation (p-PERK). Moreover, phosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a possible therapeutic target for cognitive enhancement via inhibiting Aβ levels, and we also found that ICS II markedly decreased phosphodiesterase-5A (PDE5A) expression. In conclusion, the present study demonstrates that ICS II could attenuate spatial learning and memory impairments in APP/PS1 transgenic mice. This protection appears to be due to the increased ADAM10 expression and decreased expression of both APP and BACE1, resulting in inhibition of Aβ production in the hippocampus and cortex. Inhibition of PPARγ degradation and PERK/eIF2α phosphorylation are involved in the course, therefore suggesting that ICS II might be a promising potential compound for the treatment of AD.

The spatial variability of the soil C:N ratio (C:N) influences C and N leaching and basic fertility in the field. This paper aims to identify the spatial heterogeneity of C:N in a Mollisol watershed of Northeast China and determine the main mechanisms that drive these differences. A random sampling method was used, with both geostatistical and traditional analysis being used to describe the spatial distribution of the C:N at various depths. C:N was also compared between slope position, previous vegetation and tillage methods in the watershed. The horizontal distribution of the C:N was mainly influenced by structural factors (88·4-99·9%) and often gradually deceased along the hydrographic flow direction, becoming lowest at the watershed outlet. The C:N increased as soil depth increased at all slope positions, and was higher on the back slope than on summit slope, followed by bottom slope in all soil depths. C:N was negatively (significant at p < 0·01) correlated to TN, and positively (significant at p < 0·05) correlated to elevation at all soil depths. Compared to the reforested area, C:N was typically greater in the agricultural area in the 20-60 cm depth. The planting of soybean (Glycine max L) can significantly increase the C:N at the 40-50 cm depth. C:N was higher in cross-slope tillage than in down-slope tillage, especially at soil depths of 40-50 cm. Generally, topographical factors, land use, crop planting and tillage methods can effectively influence the spatial heterogeneity of C:N in this watershed.

We also thank Prof. Dr. Yilin Wang for helping with the ITC analysis and Yang Fu for helping to draw the structures of AFGP8 and the L-proline oligomer.