New crystalline forms of hydrated
and anhydrous N-acylhydrazones are reported. The
studied crystal structures were
determined by single-crystal X-ray diffraction at 90 or 100 K. Transferred
aspherical atom model (TAAM) structure refinements were performed
with the aid of the most recent version of the University at Buffalo
Databank (UBDB). The resulting crystal structures were analyzed in
terms of molecular conformations, intermolecular interaction energies,
and crystal packing motifs. For this purpose, solid-state NMR studies
and theoretical calculations were conducted supplementarily. It was
found that all studied hydrazones adopt the E configuration
around the azine N–N bond and imino NC function in
the solid state, whereas the hydrazide N–N–CO
moiety exhibits the E and Z arrangement
in the N-acyl and N-aroyl derivatives,
respectively. The constrained energy scans confirmed the E conformation of the hydrazide unit and the E arrangement
of pyridine and hydrazone N atoms as the most stable ones. The association
modes in the studied crystals are dominated by strong hydrogen bonds
of the N–H···O or N–H···N-type
involving the amide group as a proton donor. Consequently, as indicated
by lattice energy calculations, a significant increase in the crystal
cohesive energy per asymmetric unit is observed when water molecules
are incorporated into the crystal structure, because this enables
efficient saturation of the hydrogen bond acceptor and donor atoms.
On the other hand, a substantial contribution of π···π
stacking interactions to the overall stabilization of the crystal
nets was also found. Thus, when more bulky phenyl substituents are
introduced, the cohesive energy becomes more favorable.
This study presents the synthesis and spectral analysis of new derivatives of 1,2,4-triazole-3-thione and 1,3,4-thiadiazole. New compounds were prepared by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antibacterial activity by using the agar dilution technique. Six of the compounds had potential activity against Gram-positive bacteria (minimal inhibitory concentration [MIC] = 15.63–500 μg/mL). Some compounds showed good activity especially against Bacillus subtilis ATCC 6633 (MIC = 15.63–250 μg/mL), Staphylococcus aureus ATCC 25923 (MIC = 31.25–250 μg/mL), and Micrococcus luteus ATCC 10240 (MIC = 125–250 μg/mL).Graphical abstract
By the reaction of 4-methyl-4H-1,2,4-triazole-3-thiol with ethyl bromoacetate, ethyl [(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate (1) was obtained. This compound was converted to [(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide (2). In the reaction of 2 with isothiocyanates, new thiosemicarbazides 3a-3g were obtained. The cyclization of 3a-3g in 2% aqueous solution of sodium hydroxide led to the formation of 4H-1,2,4-triazole-3(2H)-thione derivatives 4a-4g, whereas the cyclization in acid media led to the formation of 2-amino-1,3,4-thiadiazole derivatives 5a-5g. Molecular structure was confirmed by X-ray structure analysis of 3a, 4g, 5a and 5g. Compounds 4a, 4b and 4g were investigated pharmacologically to determine their effect on the central nervous system (CNS) in mice.
The reaction of sodium hydroxide with 2-aminoterephthalic acid leads to the formation of a complex of the general formula: [Na 2 (atpt)(H 2 O) 5 ]ÁH 2 O, where atpt = [NH 2 C 6 H 3 (COO) 2 ] 2-. Sodium 2-aminoterephthalate was synthesized and characterized by single-crystal X-ray diffraction, FT-IR spectroscopy, thermal analysis and coupled TG-FT-IR technique. Crystallographic study of the sodium complex reveals that the compound crystallizes in the triclinic system, the space group P-1 with a = 7.983(3) Å , b = 8.405(3) Å , c = 11.311(5) Å , a = 70.74(3)°, b = 76.57(3)°, c = 83.12(3)°and V = 696.1(5) Å 3. On heating in air atmosphere the compound in question loses all water molecules in two steps in the temperature range 30-205°C. The anhydrous form of the complex is stable up to 370°C and then decomposes to sodium carbonate.
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