Synthesis and biological activity of new derivatives of 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid

Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents

“…In addition, NH 2 and NH groups were assigned to two singlets appearing at d 4.16 and 9.00 ppm, respectively. The structure of 3 was also illustrated from its 13 H NMR and 13 C NMR spectra consistent with the assigned structures. In their IR spectra, the absorption peak corresponding to the C=N group was observed around 1642-1697 cm -1 .…”

“…The precipitate formed was fi ltered, washed with water and recrystallized from ethanol to aff ord the desired product. (11)(12)(13). General method.…”

“…Compounds bearing 1,3,4-thiadiazole moieties have displayed a number of chemotherapeutic properties including antibacterial (12), antifungal (13), antitubercular (14) and analgesic ones (15). On the other hand, Schiff bases are considered privileged structures in drug discovery, with signifi cant antimicrobial, antiviral, antifungal, antibacterial and anti-infl ammatory (16)(17)(18)(19)(20) activities as well as chelating properties towards various metal ions (21).…”

Heterocyclic Systems Containing Bridgehead Nitrogen Atom:Synthesis and Evaluation of Biological Activity of Imidazo[2,1-b]-1,3,4-thiadiazolo [2,3-c]-s-triazoles, s-Triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b]imidazo[4,5-b]quinoxaline and bis-(s-Triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b][imidazo[4,5-b]-cyclohexane]-5a,6a-diene)

“…1), that find a wide array of biological activities such as anti-fungal, 1 antibacterial, 2 anticonvulsant 3 and anticancer 4 analgesic, 5 antiinflammatory, 6 antiviral, 7 insecticide, 8 antidepressant. 9 1,3,4-Thiadiazole nucleus constitutes the active part of several biologically active compounds, including antibacterial, antifungal, antiinflammatory, 10 antitubercular 11 and leishmanicidal 12 agents. In the past years, the literature survey is enriched with progressive finding about the synthesis and pharmacological evaluation of fused heterocycles.…”

Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

“…1,2,4-Triazole and its derivatives constitute an important class of organic compounds with diverse biological activities, such as anticonvulsant, antidepressant, anti-inflammatory, antitumor, analgesic, antiviral, antibacterial and fungicidal [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Among the pharmacological profiles of 1,2,4-triazoles, their antimicrobial, anticonvulsant and antidepressant properties are best documented.…”