To
alleviate the dilemma of drug administration in Alzheimer’s
disease (AD) patients, it is of great significance to develop a new
drug delivery system. In this study, a subcutaneously implanted microneedle
(MN) device with a swellable gelatin methacryloyl (GelMA) needle body
and a dissolvable polyvinyl alcohol (PVA) backing layer was designed.
The backing layer quickly dissolved once the MN was introduced into
the subcutaneous, and the hydrogel needles were implanted in the subcutaneous
to enable prolonged drug release. Compared with oral administration,
the MN system offers the benefits of a high administration rate, a
fast onset of effect, and a longer duration of action. By detecting
the concentration of acetylcholine (ACH) and Aβ 1–42,
it was found that MN administration exhibited a stronger therapeutic
effect. The biological safety of the MN system was also assessed,
and no obvious signs of hemolysis, cytotoxicity, and inflammatory
reaction were observed. Together, these findings suggested that the
MN system is a convenient, efficient, and safe method of delivering
donepezil hydrochloride (DPH) and may provide AD patients with a novel
medicine administration option.
Wound management is a serious concern worldwide, inflicting a huge social and economic burden on patients and healthcare systems, and research into efficient wound management measures is crucial. Although traditional...
The stability of drug-loaded nanoparticles in vivo is related to the success of the drug delivery, which is investigated as a deficiency due to the limitation of traditional experimental methods. In this study, dissipative particle dynamics (DPD), a simulation method suitable for soft matter and fluids, was used to study the stability of amphiphilic nanoparticles in the blood microenvironment. By comparing the morphology alteration of nanoparticles with various molecular topologies in the shear fluid field, we have found that branch degree and geometric symmetry would be the key factors in maintaining the nanoparticle's stability. This research could provide more theoretical guidance for drug delivery system design.
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