Microneedles: a novel strategy for wound management

Zhao, Ze Qiang; Liu, Liang; Jing, Li Yue; Liu, Yue; Zhang, Yu Han; Shahbazi, Mohammad-Ali; Chen, Bo Zhi; Guo, Xin Dong

doi:10.1039/d3bm00262d

Cited by 15 publications

(8 citation statements)

References 150 publications

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“…Although some MN patches that possess similar properties, such as antibacterial and anti-inflammatory activities, have been reported for accelerating infected wound healing [ [55] , [56] , [57] ], the designed MN patch has some unique features compared with those reported systems. First, the fabrication is easy and only involves the encapsulation of probiotic in soluble matrix, which will greatly facilitate to scale up the MN patch production.…”

Section: Discussionmentioning

confidence: 99%

Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect

Jin,

Lu,

Jiang

et al. 2024

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect

Jin,

Lu,

Jiang

et al. 2024

Bioactive Materials

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“…75 The rational matching between the needle body and the base of the microneedle allows for the integration of wound detection and treatment, effectively circumventing relevant disadvantages such as challenges in exudate collection, potential harm to the wound, and time-consuming testing. 76 Gao et al 77 made full use of the base connected to the needle body and the large space and designed a microneedle base that integrates wound microenvironment detection and motion detection (Figure 4a). The base consists of one layer folded in half.…”

Section: Microneedle Structure Designmentioning

confidence: 99%

Design Strategy of Microneedle Systems for Skin Wound Healing: Based on the Structure of Tips and Therapeutic Methodologies

Ji,

Li,

et al. 2024

ACS Appl. Bio Mater.

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The skin, being the largest organ of the human body, is susceptible to damage resulting in wounds that are vulnerable to pathogenic attacks and fail to provide effective protection for internal tissues. Therefore, it is crucial to expedite wound healing. In recent years, microneedles have garnered significant attention as an innovative drug delivery system owing to their noninvasive and painless administration, simplified application process, precise control over drug release, and versatile loading capabilities. Consequently, they hold immense potential for the treatment of skin wound. This review presents a comprehensive design strategy for the microneedle system in promoting skin wound healing. First, the process of skin wound healing and the characteristics of specific wounds are elucidated. The design strategies for microneedles are subsequently presented and classified based on their structural and therapeutic methodologies. Finally, a succinct recapitulation of the previously discussed points and a prospective analysis are provided.

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“…The continuous channels formed within the gel network enable the drug to diffuse from the MNs into the skin along concentration gradients (Turner et al, 2021) (Figure 3). MNs can even be customized to monitor tissue interstitial fluids to achieve control drug release (Ullah et al, 2021;Shao et al, 2022;Zhao et al, 2023b).…”

Section: Manufacture and Therapeutic Advantages Of Microneedles In Wo...mentioning

confidence: 99%

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Tang,

Li,

You

et al. 2023

Front. Bioeng. Biotechnol.

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Wound healing is a dynamic and complex restorative process, and traditional dressings reduce their therapeutic effectiveness due to the accumulation of drugs in the cuticle. As a novel drug delivery system, microneedles (MNs) can overcome the defect and deliver drugs to the deeper layers of the skin. As the core of the microneedle system, loaded drugs exert a significant influence on the therapeutic efficacy of MNs. Metallic elements and herbal compounds have been widely used in wound treatment for their ability to accelerate the healing process. Metallic elements primarily serve as antimicrobial agents and facilitate the enhancement of cell proliferation. Whereas various herbal compounds act on different targets in the inflammatory, proliferative, and remodeling phases of wound healing. The interaction between the two drugs forms nanoparticles (NPs) and metal-organic frameworks (MOFs), reducing the toxicity of the metallic elements and increasing the therapeutic effect. This article summarizes recent trends in the development of MNs made of metallic elements and herbal compounds for wound healing, describes their advantages in wound treatment, and provides a reference for the development of future MNs.

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Microneedles: a novel strategy for wound management

Abstract: Wound management is a serious concern worldwide, inflicting a huge social and economic burden on patients and healthcare systems, and research into efficient wound management measures is crucial. Although traditional...

Cited by 15 publications

References 150 publications

Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect

Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect

Design Strategy of Microneedle Systems for Skin Wound Healing: Based on the Structure of Tips and Therapeutic Methodologies

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

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