With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. Local descriptors account for the interactions between residues in both continuous and discontinuous regions of a protein sequence, so this method enables us to extract more PPI information from the sequence. A series of elaborate experiments are performed to optimize the prediction model by varying the parameter k and the distance measuring function of the k-nearest neighbors learning system and the ways of coding a protein pair. When performed on the PPI data of Saccharomyces cerevisiae, the method achieved 86.15% prediction accuracy with 81.03% sensitivity at the precision of 90.24%. An independent data set of 986 Escherichia coli PPIs was used to evaluate this prediction model and the prediction accuracy is 73.02%. Given the complex nature of PPIs, the performance of our method is promising, and it can be a helpful supplement for PPIs prediction.
Recovering whole-body mesh by inferring the abstract pose and shape parameters from visual content can obtain 3D bodies with realistic structures. However, the inferring process is highly non-linear and suffers from image-mesh misalignment, resulting in inaccurate reconstruction. In contrast, 3D keypoint estimation methods utilize the volumetric representation to achieve pixel-level accuracy but may predict unrealistic body structures. To address these issues, this paper presents a novel hybrid inverse kinematics solution, HybrIK, that integrates the merits of 3D keypoint estimation and body mesh recovery in a unified framework. HybrIK directly transforms accurate 3D joints to body-part rotations via twist-and-swing decomposition. The swing rotations are analytically solved with 3D joints, while the twist rotations are derived from visual cues through neural networks. To capture comprehensive whole-body details, we further develop a holistic framework, HybrIK-X, which enhances HybrIK with articulated hands and an expressive face. HybrIK-X is fast and accurate by solving the whole-body pose with a one-stage model. Experiments demonstrate that HybrIK and HybrIK-X preserve both the accuracy of 3D joints and the realistic structure of the parametric human model, leading to pixel-aligned whole-body mesh recovery. The proposed method significantly surpasses the state-of-the-art methods on various benchmarks for body-only, hand-only, and whole-body scenarios. Code and results can be found at https://jeffli.site/HybrIK-X/.
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