Iron was used as the catalyst for the direct C-H functionalization/C-S bond formation under mild conditions. Various substrates could afford benzothiazoles in moderate to excellent yields. Preliminary mechanistic studies revealed that pyridine played a crucial role for the high yields and selectivities.

Generative adversarial networks (GANs) are a hot research topic recently. GANs have been widely studied since 2014, and a large number of algorithms have been proposed. However, there is few comprehensive study explaining the connections among different GANs variants, and how they have evolved. In this paper, we attempt to provide a review on various GANs methods from the perspectives of algorithms, theory, and applications. Firstly, the motivations, mathematical representations, and structure of most GANs algorithms are introduced in details. Furthermore, GANs have been combined with other machine learning algorithms for specific applications, such as semi-supervised learning, transfer learning, and reinforcement learning. This paper compares the commonalities and differences of these GANs methods. Secondly, theoretical issues related to GANs are investigated. Thirdly, typical applications of GANs in image processing and computer vision, natural language processing, music, speech and audio, medical field, and data science are illustrated. Finally, the future open research problems for GANs are pointed out.

Motivation: High-throughput protein interaction data, with everincreasing volume, are becoming the foundation of many biological discoveries, and thus high-quality protein-protein interaction (PPI) maps are critical for a deeper understanding of cellular processes. However, the unreliability and paucity of current available PPI data are key obstacles to the subsequent quantitative studies. It is therefore highly desirable to develop an approach to deal with these issues from the computational perspective. Most previous works for assessing and predicting protein interactions either need supporting evidences from multiple information resources or are severely impacted by the sparseness of PPI networks. Results: We developed a robust manifold embedding technique for assessing the reliability of interactions and predicting new interactions, which purely utilizes the topological information of PPI networks and can work on a sparse input protein interactome without requiring additional information types. After transforming a given PPI network into a low-dimensional metric space using manifold embedding based on isometric feature mapping (ISOMAP), the problem of assessing and predicting protein interactions is recasted into the form of measuring similarity between points of its metric space. Then a reliability index, a likelihood indicating the interaction of two proteins, is assigned to each protein pair in the PPI networks based on the similarity between the points in the embedded space. Validation of the proposed method is performed with extensive experiments on densely connected and sparse PPI network of yeast, respectively. Results demonstrate that the interactions ranked top by our method have high-functional homogeneity and localization coherence, especially our method is very efficient for large sparse PPI network with which the traditional algorithms fail. Therefore, the proposed algorithm is a much more promising method to detect both false positive and false negative interactions in PPI networks. Availability: MATLAB code implementing the algorithm is available from the web site

With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. Local descriptors account for the interactions between residues in both continuous and discontinuous regions of a protein sequence, so this method enables us to extract more PPI information from the sequence. A series of elaborate experiments are performed to optimize the prediction model by varying the parameter k and the distance measuring function of the k-nearest neighbors learning system and the ways of coding a protein pair. When performed on the PPI data of Saccharomyces cerevisiae, the method achieved 86.15% prediction accuracy with 81.03% sensitivity at the precision of 90.24%. An independent data set of 986 Escherichia coli PPIs was used to evaluate this prediction model and the prediction accuracy is 73.02%. Given the complex nature of PPIs, the performance of our method is promising, and it can be a helpful supplement for PPIs prediction.

Learning-based hashing algorithms are "hot topics" because they can greatly increase the scale at which existing methods operate. In this paper, we propose a new learning-based hashing method called "fast supervised discrete hashing" (FSDH) based on "supervised discrete hashing" (SDH). Regressing the training examples (or hash code) to the corresponding class labels is widely used in ordinary least squares regression. Rather than adopting this method, FSDH uses a very simple yet effective regression of the class labels of training examples to the corresponding hash code to accelerate the algorithm. To the best of our knowledge, this strategy has not previously been used for hashing. Traditional SDH decomposes the optimization into three sub-problems, with the most critical sub-problem - discrete optimization for binary hash codes - solved using iterative discrete cyclic coordinate descent (DCC), which is time-consuming. However, FSDH has a closed-form solution and only requires a single rather than iterative hash code-solving step, which is highly efficient. Furthermore, FSDH is usually faster than SDH for solving the projection matrix for least squares regression, making FSDH generally faster than SDH. For example, our results show that FSDH is about 12-times faster than SDH when the number of hashing bits is 128 on the CIFAR-10 data base, and FSDH is about 151-times faster than FastHash when the number of hashing bits is 64 on the MNIST data-base. Our experimental results show that FSDH is not only fast, but also outperforms other comparative methods.

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Feature selection (FS) is an important component of many pattern recognition tasks. In these tasks, one is often confronted with very high-dimensional data. FS algorithms are designed to identify the relevant feature subset from the original features, which can facilitate subsequent analysis, such as clustering and classification. Structured sparsity-inducing feature selection (SSFS) methods have been widely studied in the last few years, and a number of algorithms have been proposed. However, there is no comprehensive study concerning the connections between different SSFS methods, and how they have evolved. In this paper, we attempt to provide a survey on various SSFS methods, including their motivations and mathematical representations. We then explore the relationship among different formulations and propose a taxonomy to elucidate their evolution. We group the existing SSFS methods into two categories, i.e., vector-based feature selection (feature selection based on lasso) and matrix-based feature selection (feature selection based on l-norm). Furthermore, FS has been combined with other machine learning algorithms for specific applications, such as multitask learning, multilabel learning, multiview learning, classification, and clustering. This paper not only compares the differences and commonalities of these methods based on regression and regularization strategies, but also provides useful guidelines to practitioners working in related fields to guide them how to do feature selection.

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