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A silk suture placed in the lumen of one uterine horn of rats before mating prevented pregnancy in that horn although normal implantation occurred in the unoperated horn. The suture did not interfere with fertilization or the tubal transport of ova, nor did it induce a decidual reaction; it appeared to prevent pregnancy by causing failure of implantation.

Adult female mice with an intra-uterine foreign body in one horn were mated to normal males. Females were killed on Days 2 to 11, the reproductive tracts were removed, implantations were counted and the uteri and tubes were flushed to recover unimplanted ova. None of the thirty-two females killed after Day 5 had any evidence of implantations in the operated horn, and only 28% had implantations in the control horn. Forty-five per cent of these females had an average of3 \ m=. \ 9ova in the tubes of the operated side at this time, a finding which could not be explained by any gross anatomical alteration. Fifteen animals killed prior to implantation confirmed the fact that sperm transport and fertilization did occur in both operated and control sides, but that tubal transport of ova was altered on the operated side. All of the ova remained in the tube on Day 4 when ova on the control side were recovered from the uterus.

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