The Effect of an Iufb on Reproduction in Mice

Doyle, Lee Lee; Margolis, Alan J.

doi:10.1530/jrf.0.0110027

Cited by 33 publications

(16 citation statements)

References 7 publications

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“…It is interest¬ ing to contrast this with the observations made on IUD-bearing mice. Greenwald (1965), Doyle & Margolis (1966), Marston & Kelly (1969) and Martin & Finn (1970) all agree that there is extensive infiltration of leucocytes into the stroma and the lumen of an IUD-bearing uterine horn. According to Martin & Finn, the effect seemed to be a local one, with many luminal leucocytes in the vicinity of the IUD, the numbers decreasing with distance.…”

Section: Discussionmentioning

confidence: 89%

Leucocytes in the Luminal Epithelium of the Mouse Uterus at Implantation

Smith¹,

Wilson²

1974

Reproduction

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Observations were made on the infiltration of leucocytes into the luminal epithelium of the mouse uterus at the time of implantation.While the blastocyst was still surrounded by the zona pellucida there were very few leucocytes in the epithelium. After loss of the zona pellucida, 75% of the blastocysts had one or more leucocytes/1-\g=m\m section in the epithelial layer surrounding them. The presence of thorotrast particles in the leucocytes showed almost all of these cells to be phagocytic. They were always found low in the epithelial layer, near the basement membrane, and with one exception (possibly an abnormal animal) were never seen in the uterine lumen. This situation contrasts with that seen in the IUD-bearing mouse, in which there is extensive infiltration of the epithelium and of the lumen by leucocytes.

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Section: Discussionmentioning

confidence: 89%

Leucocytes in the Luminal Epithelium of the Mouse Uterus at Implantation

Smith¹,

Wilson²

1974

Reproduction

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“…Unilateral uterine silk sutures induce unilateral sterility in rats, but most workers have found they induce bilateral sterility in mice. This appears to be due to the effective continuity of the uterine lumina between the two horns in most strains studied (Doyle & Margolis, 1966;Marston & Kelly, 1969a, b). We have consistently found unilateral silk threads to induce bilateral sterility , epithelial leucocytosis and epithelial abnormalities (Martin & Finn, 1978) in a minority of mice of our strain.…”

Section: Discussionmentioning

confidence: 96%

Varying effects of an IUD on decidualization in mice

Martin¹,

Finn²

1979

Reproduction

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Chronically implanted IUDs consisting of silk suture threads induced decidualization in regions of the uterus remote from the suture site in ovariectomized mice treated with a regimen of progesterone and oestrogen which sensitizes the uterus to a decidual stimulus. In these conditions the IUDs did not inhibit decidualization induced by instilled oil, although they did so in pregnant animals of the same strain. Varying the dose of progesterone and oestrogen did not produce conditions in which IUD's inhibited oil-induced decidualization in ovariectomized mice and progesterone treatment did not prevent IUDs inhibiting decidualization in pregnant animals. However, when ovariectomized mice, sensitized as before, were primed repeatedly with oestrogen to simulate continuing oestrous cycles after IUD insertion, the IUD's inhibited oil-induced decidualization. This involved the premature loss of instilled oil from the uterine lumen and was associated with heavy infiltration of leucocytes into the luminal epithelium. Numbers of leucocytes free in the uterine lumen did not appear to be critical. It appears that contact between the oil and the luminal epithelial surface must be sustained for some length of time to induce a decidual reaction; brief contact is not sufficient to trigger the response.

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“…2). Doyle and Margolis (5) found that the entire mouse horn containing a foreign body was infertile, and that the fertility of the control horn was also markedly reduced. Thus the pattern of infertility in the mouse also corresponded to the pattern of polymorphonuclear leukocyte infiltration.…”

Section: Conventional Rats--as Seen Inmentioning

confidence: 99%

The Relationship of Polymorphonuclear Leukocytes to Infertility in Uteri Containing Foreign Bodies

Parr

Schaedler

Hirsch

1967

The Journal of Experimental Medicine

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The intrauterine contraceptive device is a potentially important factor in the world population problem, primarily became it provides an effective method of contraception that does not require continuous motivation on the part of the user. In addition, its cost is trivial, its insertion requires only a few minutes, and normal fertility returns quickly after its removal. There is also some reason (1, 2) to hope that the difficulties in its use, such as expulsions and rare pregnancies, can be overcome, since we still have much to learn about it. Even the basis of its contraceptive action remains unknown.Previous observations in the rat and other species indicated that a foreign body in the uterus had no systemic effect, but only a local effect in the uterus. This local effect in the uterus appeared to be a direct toxicity for blastocysts or spermatozoa, rather than an inhibition of implantation. For example, a foreign body in the rat uterus (3, 4) had no effect on fertilization or tubal transport of ova, but a few hours after blastocysts entered the horn containing a foreign body they could no longer be recovered; blastocysts could be recovered from control horns for about 24 hr. Thus, in the rat horn containing a foreign body, blastocysts were no longer present at the time of implantation. In the mouse (5), similar observations were made, and in addition it was noted that spermatozoa were killed. In the sheep (6), spermatozoa were killed in the uterus and fertilization was prevented. And in the rabbit (7), pregnancy occurred throughout the uterus except for the portion in direct contact with the foreign body. Observations such as these have led to the notion that a foreign body creates a hostile environment in the uterus (8). The experiments reported here clarify the role of inflammation and of infection in the infertility of uteri containing a foreign body. fig. 1 is a diagram of the rodent uterus, detailing the regions of special interest in these studies. The region FB (foreign body) was the segment of the uterine horn which contained Materials and Methods Text-

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The Effect of an Iufb on Reproduction in Mice

Cited by 33 publications

References 7 publications

Leucocytes in the Luminal Epithelium of the Mouse Uterus at Implantation

Leucocytes in the Luminal Epithelium of the Mouse Uterus at Implantation

Varying effects of an IUD on decidualization in mice

The Relationship of Polymorphonuclear Leukocytes to Infertility in Uteri Containing Foreign Bodies

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