Intrauterine Foreign Body. I. Effect on Reproductive Processes in the Rat

Doyle, Lee Lee; Margolis, Alan J.

doi:10.1097/00006254-196508000-00016

Cited by 10 publications

(12 citation statements)

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“…(Doyle & Margolis, 1964;Greenwald, 1965;Craig, 1969;Ishihama & Miyai, 1969). In this report, it has been conclusively shown that oviducal embryos are still fully viable on Day 4 (Table 2).…”

Section: Effect Of Ovariectomy and An Iud On Embryonic Mortalitysupporting

confidence: 51%

“…Day 1 of pregnancy was the day on which spermatozoa were found in the vaginal smear. Pseudopregnancy was induced by stimulating the cervix of pro-oestrous or oestrous rats for 20 sec with a vibrating rod held in an electric engraver (DeFeo, 1966 (Doyle & Margolis, 1964;Greenwald, 1965;Craig, 1969; (Snedecor & Cochran, 1967) and subjected to analy¬ sis of variance and regression analysis. The slope of the line for the non-IUD horn did not differ significantly from zero (P>0-05).…”

Section: Methodsmentioning

confidence: 99%

“…In this report, it has been conclusively shown that oviducal embryos are still fully viable on Day 4 (Table 2). Normal blastocysts cannot be recovered from the IUD-bearing uterus on the morning of Day 5 (Doyle & Margolis, 1964;Greenwald, 1965). The loss of rat embryos must, therefore, occur after the evening of Day 4 and before noon on Day 5.…”

Section: Effect Of Ovariectomy and An Iud On Embryonic Mortalitymentioning

confidence: 99%

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Survival of Embryos Transferred Into the Iud-Bearing Uterus of the Rat

DeBoer¹,

Anderson²

1971

Reproduction

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Section: Effect Of Ovariectomy and An Iud On Embryonic Mortalitysupporting

confidence: 51%

Section: Methodsmentioning

confidence: 99%

Section: Effect Of Ovariectomy and An Iud On Embryonic Mortalitymentioning

confidence: 99%

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Survival of Embryos Transferred Into the Iud-Bearing Uterus of the Rat

DeBoer¹,

Anderson²

1971

Reproduction

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“…The activity of phosphodiesterase was assayed as described by Sim & Chantharaksri (1973 In the rat, Doyle & Margolis (1964) have shown that the presence of an IUD prevents implantation, which normally occurs between Days 4 and 5, i.e. the days in the present study on which the presence of an IUD induced peak differences in cyclic AMP levels.…”

mentioning

confidence: 83%

Effect of Iud on Uterine Cyclic Amp and the Activities of Adenyl Cyclase and Phosphodiesterase During the Oestrous Cycle and Early Pregnancy in Rats

Sim¹

1974

Reproduction

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“…With regard to the influence of the IUD on the estrus cycle in rats, we have only the report of Doyle and Margolis (1964), who utilized a silk-IUD and noted an apparent effect on the cycle. In the first of our experiments, no altera tions were observed in the estrus cycle.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Contraceptive Mechanism of the Cu-Intrauterine Device and the Plastic-Intrauterine Device in Rats

Takahashi¹,

Hirose²,

Haneda³

et al. 1978

Tohoku J. Exp. Med.

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Comparative Study of the Contraceptive Mechanism of the Cu-Intra uterine Device and the Plastic-Intrauterine Device in Rats. Tohoku J. exp. Med., 1978, 126 (4) 325-333 -After inserting the Cu-IUD and plastic-IUD into the horn of the uterus of rats, vaginal smears were daily observed for twelve estrus cycles, but no abnormal changes were noted. The female rats with the IUD were exposed to impregnation placing together with male rats. Neither the Cu-IUD nor the plastic-IUD affected copulation, and a complete contraceptive result was obtained in these rats. There were no significant differences in any effect examined between Cu-IUD and plastic-IUD groups. In order to investigate the influence of copper on the penetration of sperm, we placed the rats with the IUD under direct observation and then exposed them to natural copulation.By examining various sites of the reproductive organs 30 min after copulation, the hindrance of sperm migration by the Cu-IUD was confirmed.IUD; experimental study of contraception; ratWith worldwide expansion of population becoming an everincreasing social problem, researches concerning contraception are of great significance, and various contraceptive methods are being investigated on all quarters. Among these are oral contraceptive (pill) and intrauterine devices (IUD), methods which are valued for their superior results and which represent the most widely disseminated birthcontrol techniques to date.With regard to the IUD, besides the heretofore utilized inert IUD, the active IUD has been developed and reported as manifesting a higher level of contraceptive effect. However, as for the mechanism through which the active IUD functions, there are numerous aspects which remain as yet unclear.The purpose of the present paper is to elucidate the mechanism of the contraceptive action of the Cu-IUD in rats.The experiments were performed with respect to its influence on the estrus cycle and on sperm deposited in the female reproductive tract.On all points a comparative study utilizing the plastic-IUD vis-a-vis the Cu-IUD was concurrently conducted.Received for publication, February 8, 1978. 325

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Intrauterine Foreign Body. I. Effect on Reproductive Processes in the Rat

Cited by 10 publications

References 0 publications

Survival of Embryos Transferred Into the Iud-Bearing Uterus of the Rat

Survival of Embryos Transferred Into the Iud-Bearing Uterus of the Rat

Effect of Iud on Uterine Cyclic Amp and the Activities of Adenyl Cyclase and Phosphodiesterase During the Oestrous Cycle and Early Pregnancy in Rats

A Comparative Study of the Contraceptive Mechanism of the Cu-Intrauterine Device and the Plastic-Intrauterine Device in Rats

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