Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused high mortality in patients with hematological malignancies (HM). 1 The newly emerged omicron variants of SARS-CoV-2 harbor multiple novel spike protein mutations that raise concerns about vaccine efficiency and antiviral efficacy of the available therapeutic monoclonal antibodies. 2 The first published clinical data in immunocompetent patients have found that infection with omicron variants is associated with reduced vaccine efficiency compared to the delta variants, but decreased hospital admission and mortality. 3,4 Preliminary, prepublished, data from a large case-control study have shown that the vaccine effect against omicron in immunocompromised patients, including HM patients, is even more reduced, but data regarding clinical outcomes are lacking. 5 The aim of this study was to describe risk factors, antiviral treatment and outcomes of SARS-CoV-2 omicron variant infection in 593 HM patients included in the EPICOVIDEHA registry.EPICOVIDEHA is an international open web-based registry for patients with HM infected with SARS-CoV-2. 1,6 Both hospitalized and nonhospitalized patients are eligible for inclusion. The questionnaire includes data on the HM, SARS-CoV-2 vaccination status, risk factors for severe COVID-19 infection, SARS-CoV-2 virus variant, antiviral treatment, and outcomes including mortality (eFigure 1 and eTable 4).

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes life-threatening COVID-19 in hematologic malignancy (HM) patients, associated with high morbidity and mortality in this particularly vulnerable population. 1 After more than 2 years since the beginning of the COVID-19 pandemic, several prophylactic and therapeutic strategies have been developed against SARS-CoV-2, including targeted antivirals, monoclonal antibodies and vaccines, leading

Several hundred millions of people have been diagnosed of coronavirus disease 2019 (COVID-19), causing millions of deaths and a high socioeconomic burden. SARS-CoV-2, the causative agent of COVID-19, induces both specific T- and B-cell responses, being antibodies against the virus detected a few days after infection. Passive immunization with hyperimmune plasma from convalescent patients has been proposed as a potentially useful treatment for COVID-19. Using an in-house quantitative ELISA test, we found that plasma from 177 convalescent donors contained IgG antibodies specific to the spike receptor-binding domain (RBD) of SARS-CoV-2, although at very different concentrations which correlated with previous disease severity and gender. Anti-RBD IgG plasma concentrations significantly correlated with the plasma viral neutralizing activity (VN) against SARS-CoV-2 in vitro. Similar results were found using an independent cohort of serum from 168 convalescent health workers. These results validate an in-house RBD IgG ELISA test in a large cohort of COVID-19 convalescent patients and indicate that plasma from all convalescent donors does not contain a high enough amount of anti-SARS-CoV-2-RBD neutralizing IgG to prevent SARS-CoV-2 infection in vitro. The use of quantitative anti-RBD IgG detection systems might help to predict the efficacy of the passive immunization using plasma from patients recovered from SARS-CoV-2.

El presente artículo tiene como objetivo aportar algunas reflexiones acerca de la potencialidad del aprendizaje-servicio desde un punto de vista territorial. La construcción de apuestas educativas en el ámbito local a través del aprendizaje-servicio permite superar el desarrollo de experiencias concretas y aisladas y avanzar hacia la construcción de redes educativas que tienen un horizonte de bien común. Los aportes en este sentido parten de una investigación experiencial de corte cualitativo que ha combinado el análisis documental de diferentes experiencias anteriores y el proceso de investigación-acción realizado en tres territorios catalanes (Barcelona, Sant Cugat y Puig-Reig). En este texto se exponen las principales líneas de acción a desarrollar desde la perspectiva de facilitación y/o coordinación en el proceso de implementar el aprendizaje-servicio a nivel territorial: aproximación al territorio, diagnóstico compartido; generación de proyectos; y comunicación de la apuesta territorial. La reflexión acerca de este proceso subraya que todas ellas se sustentan en base a principios como la apertura, el reconocimiento, la coherencia y la sostenibilidad, entre otros. Asimismo, el trabajo también apunta algunas reflexiones acerca de la agencia educativa por parte de otros agentes del territorio, más allá de los centros educativos, y el fortalecimiento del trabajo en red para generar territorios más educadores.

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The influence of geomorphology on the composition of aquatic flora and fauna within a temporary pond network Geomorphological and hydrological features can provide a sound basis for global wetland classification. Temporary ponds located on the sandy area of Doñana can be classified into five different geomorphological areas. We hypothesised that these ponds would differ in soil characteristics, which may also explain differences in the composition of their macroinvertebrate, amphibian, and aquatic plant species assemblages. The study ponds were significantly segregated into southern and northern geomorphological areas based on the depth to the water table. The results of the multivariate ordination of soil variables were consistent with a north-south segregation, which was explained by the carbonate and other main ion concentrations in the pond basins. The ponds located in ecotones (marsh-sand and stable-mobile dunes) were particularly rich in amphibians and macroinvertebrates. This result may be explained because the ponds with the longest permanence of water were located in these areas, which represented the only flooded ponds during droughts. In addition, they also contained a high number of temporary ponds, thus favouring connectivity and environmental heterogeneity in these areas.