Our results indicate the curative role of vitamin D treatment on the androgen excess in PCOS rat model which causes abnormalities in ovarian morphology and functions. Vitamin D has positive effects on the hormonal and structural changes observed in PCOS, but it has been concluded that long-term use may be more beneficial.
Angiogenesis is the process of new capillary formation from preexisting vessels that occurs in both the physiological and pathological processes in our body. Ovarian angiogenesis participates in normal ovarian physiologic activation, various ovarian diseases and neoplasms throughout the follicular and luteal phases of the ovarian cycle. The normal ovarian function modulated by a wide range of proangiogenic and antiangiogenic factors that directly affects angiogenesis. The most important of these factors are vascular endothelial growth factor, epidermal growth factor, fibroblast growth factor, angiotensin ıı, matrix metalloproteinases as well as many other factors are involved in this process. Today increased knowledge in this issues will enable the emergence of new therapeutic approaches in the understanding and treatment of pathogenesis of many diseases.
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