In an attempt to synthesize antibacterial agents effective against gram‐positive and gram‐negative bacteria, the efficient synthesis of novel bis‐azetidinones (3a–j) has been established. Thus, cycloaddition reaction of substituted bis‐imines with chloroacetylchloride under microwave irradiation in the presence of zeolite yielded bis‐azetidinones (3a–j). Structures of the synthesized compounds have been elucidated on the basis of their elemental analysis and spectral data (IR, 1H‐NMR, 13C‐NMR, and mass spectra). The synthesized bis‐azetidinones were screened for their antibacterial activity against five microorganisms: Bacillus subtilis, Proteus vulgaris, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. They were found to exhibit good to moderate antibacterial activity.
Density and viscosity data for L-Arginine (L-Arginine + NaCl + water) systems were determined at 288.15 K and 298.15 K. The density data has been utilized to calculate apparent molar volume, limiting apparent molar volume, partial molar volume of transfer and limiting apparent molar expansivity. The viscosity data have been used to calculate coefficient of viscosity, relative viscosity and B coefficients. These thermophysical properties are used in understanding the interactions between solute-solvent and structure making or breaking ability of the solute.
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