Nicotine absorption after use of the vapour inhaler occurs primarily via the mucosa of the oral cavity; the absorption occurs slowly and the arterial nicotine concentration spike, typical of cigarette smoking, is avoided. Thus, the likelihood for abuse of the nicotine inhaler is probably small.

Even though statistically significant differences were observed, the disposition of nicotine does not seem to be changed to a clinically important extent in elderly subjects compared with younger adults.

Progressive kidney failure is associated with a gradual decrease of renal and nonrenal elimination of nicotine.

Our results are consistent with nicotine-dependent changes in EEG measures indicative of arousal.