Site of nicotine absorption from a vapour inhaler - comparison with cigarette smoking

Lunell, Erik; Molander, Lars; Ekberg, Karin; Wahren, John

doi:10.1007/s002280050007

Cited by 86 publications

(62 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three fundamental concepts help to develop a deeper understanding. First, the magnitude of nicotine's impact on the brain relates to the rate of its delivery to the brain, suggesting that characteristics of the delivery device may also contribute to the motivating potential of the drug [7]. Second, nicotine bypasses normal sensory input pathways to directly affect the organism's most fundamental survival instincts and thereby influences behavioural decisions more profoundly than even starvation or pain [8].…”

Section: Genetics and Psychology Of Tobacco Addictionmentioning

confidence: 99%

Tobacco use in relation to COPD and asthma

Hylkema¹,

Sterk²,

Boer³

et al. 2007

European Respiratory Journal

View full text Add to dashboard Cite

Smoking is the leading cause of preventable death worldwide. Hundreds of millions of individuals still smoke, affecting their health as well as that of their peers, family and offspring. Smoking is a well-established prime risk factor for chronic obstructive pulmonary disease and hampers the response to treatment in asthma and chronic obstructive pulmonary disease. In the present paper, new concepts are discussed with respect to pathology, treatment, smoking cessation and tobacco control. Recommendations for future directions are given.

show abstract

Section: Genetics and Psychology Of Tobacco Addictionmentioning

confidence: 99%

Tobacco use in relation to COPD and asthma

Hylkema¹,

Sterk²,

Boer³

et al. 2007

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…The lag time between a puff of a cigarette and nicotine reaching the brain is 10 to 20 s. Although the delivery of nicotine to the brain is rapid, there is nevertheless significant pulmonary uptake and some delayed release of nicotine as evidenced by pulmonary positron emission tomography data and the slow decrease in the arterial concentrations of nicotine between puffs Rose et al, 1999). Nicotine concentrations in arterial blood after smoking a cigarette can be quite high, reaching up to 100 ng/ml, but usually ranging between 20 and 60 ng/ml (Armitage et al, 1975;Gourlay and Benowitz, 1997;Rose et al, 1999;Lunell et al, 2000). The usual peak arterial nicotine concentration after the first puff is lower, averaging 7 ng/ml (Rose et al, 1999).…”

mentioning

confidence: 99%

Metabolism and Disposition Kinetics of Nicotine

2005

View full text Add to dashboard Cite

“…48 The product is not a true inhaler, as absorption is primarily by oral mucosa rather than through the bronchi or lungs. 49 Nicotine delivered via this method is 36% absorbed into the oral cavity, 36% in the oesophagus and stomach, and only 4% by the lung. 50 A dose consists of a puff or inhalation.…”

Section: Nicotine Inhalermentioning

confidence: 99%

Nicotine-replacement therapy: a proven treatment for smoking cessation

Robson

2010

South African Family Practice

View full text Add to dashboard Cite

Smoking is a major cause of cardiovascular diseases, respiratory diseases and cancer. Despite the high prevalence of smokers worldwide, smokers are often neglected and not offered effective assistance with quitting their habits. In order to overcome this public health burden, effective treatment is needed to help smokers stop smoking. Among the pharmacological treatments available, nicotine-replacement therapy (NRT), when prescribed in combination with behavioural support, has been proven to be effective in helping a wide range of smokers to quit. NRT helps smokers during the withdrawal process by replacing a proportion of the nicotine formerly obtained from cigarettes. NRT is available in many formulations. The commonly prescribed formulations are nicotine gum, nicotine patches, nicotine inhaler and nicotine nasal spray. The choice of which NRT to prescribe depends on the patient's condition, established guidelines and protocols and availability. This article aims to review the role of NRT in smoking cessation.Peer reviewed.

show abstract

Site of nicotine absorption from a vapour inhaler - comparison with cigarette smoking

Cited by 86 publications

References 12 publications

Tobacco use in relation to COPD and asthma

Tobacco use in relation to COPD and asthma

Metabolism and Disposition Kinetics of Nicotine

Nicotine-replacement therapy: a proven treatment for smoking cessation

Contact Info

Product

Resources

About