Software has been developed for reduction of automatic analyzer data both for on-line and off-line modes, using a PDP-12 minicomputer with 8K core memory, magnetic tape and disk storage, a multiplexer and 16 channel 10-bit analog-to-digital converter, and a cathode ray tube. The on-line system performs data-logging onto magnetic tape of 16 instruments asynchronously, displaying any 2 analog-to-digital conversion channels on the cathode ray tube in real-time. Spectrophotometers are interfaced to the computer, using economically constructed operational amplifier circuits. Data reduction is aided by a hardware floating-point processor, using an 8-point least-squares fitting algorithm to digitally smooth the data array and determine each peak maximum. Computer results of 3 different systems operating simultaneously are compared to values obtained manually. The off-line system was written using FOCAL-12 conversational language and will accept digital values by Teletype, peak detector paper punch, or TWX; the latter makes the program available to other laboratories through the Federal Telecommunications TWX System.
Four years ago, an agency decision was made to investigate the applicability of the on-line minicomputer in Food and Drug Administration district laboratories. Although several -
The DC and AC polarographic response of nitroglycerin in the nonaqueous medium of acetonitrile-0.1M tetrabutylammonium perchlorate is presented. DC polarographic results are shown to be superior with respect to sensitivity limits and linearity of the response (wave height) vs. concentration profile. DC polarography is applied successfully to the analysis of two types of commercial formulations containing nitroglycerin. The results are compared with other methods for the determination of nitroglycerin, e.g., infrared, the phenoldisulisulfonic acid procedure for organic nitrates, and a column chromatographic procedure.
A 6’ column containing 3% OV-17 on Gas Chrom Q was evaluated as a universal GLC column for pharmaceuticals. With isothermal column temperatures ranging from 50 to 300°C, the following have been chromatographed: alcohols, anesthetics, anticholinergics, antihistamines, antiseptics, barbiturates, sterols, steriods, sulfonamides, sympathomimetics, and xanthine alkaloids.
As electronic balances replace mechanical balances in teaching institutions, balance instruction must change from applied classical mechanics to principles of calibration.
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