Nonaqueous Polarographic Analysis of Nitroglycerin

Abstract

The DC and AC polarographic response of nitroglycerin in the nonaqueous medium of acetonitrile-0.1M tetrabutylammonium perchlorate is presented. DC polarographic results are shown to be superior with respect to sensitivity limits and linearity of the response (wave height) vs. concentration profile. DC polarography is applied successfully to the analysis of two types of commercial formulations containing nitroglycerin. The results are compared with other methods for the determination of nitroglycerin, e.g., infrared, the phenoldisulisulfonic acid procedure for organic nitrates, and a column chromatographic procedure.

Organic polarography

“…Oscillographic polarography was used to determine nitrocellulose and polyvinyl nitrate (742), nitro derivatives used in explosives (770), and dinitro-ocresol in water (878). Nitroglycerine was determined by ac and dc polarography (968), while 1 -[ 5-(4-nitropheny 1)fuf ury lideneamino ]hydantoin sodium salt hydrate (Dantrolene Sodium) was analyzed by differential, pulse polarography (166). 2,4-Dichlorophenoxyacetic acid in blood and urine (236), phenazone (323,676), 4,4'-thiobis (6-ieri-butyl-m-cresol) (472), benzene (607), 4-hydroxy benzoic acid esters (894), and phenothiazine (921) were determined polarographically after a nitration procedure.…”