All-Purpose Gas-Liquid Chromatographic Column for Pharmaceuticals

Abstract

A 6’ column containing 3% OV-17 on Gas Chrom Q was evaluated as a universal GLC column for pharmaceuticals. With isothermal column temperatures ranging from 50 to 300°C, the following have been chromatographed: alcohols, anesthetics, anticholinergics, antihistamines, antiseptics, barbiturates, sterols, steriods, sulfonamides, sympathomimetics, and xanthine alkaloids.

USP Collaborative Study of the Assay of Atropine and Scopolamine Dosage Forms

“…Penner (16) studied atropine assay by GLC, both as a silyl derivative and later untreated, using tetraphenylethylene as the internal standard. Alber (17) recently reported a broad study of the gas chromatography of drugs and alkaloids using the methylphenylpolysiloxane liquid phase which was used in this collaboration.…”