Previously we have reported on the antiinflammatory [1] and antiviral [2] properties of 1,4,5-trisubstituted tetrahydropyrrole-2,3 -diones.tn continuation of the search for biologically active compounds in the series of substituted tetrahydropyrrole-2,3-diones (structurally similar to pyracetam), it was of interest to attempt their synthesis by the method described in [2], using natural co-and 13-amino acids as the amino components, and study the nootropic, antibacterial, antiinflammatory, and analgesic activity.For this purpose we have studied the interaction of methyl ester of acetylpyruvic acid with a mixture of an aromatic aldehyde and amino acid. Our experiments showed that short-time heating of glycine (as the amino acid) in alcohol, followed by holding the reaction mixture at room temperature, leads to 5-aryl-4-acetyl-l-carboxyalkyltetrahydropyrrole-2,3-diones (I -V) with good yield.
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