The reaction of methyl esters of acylpyruvic acids, 4-aminophenols, and aromatic aldehydes leads to the formation of 1-(4-hydroxyphenyl)-4-acyl-5-aryl-3-hydroxy-3-pyrrolin-2-ones. The proposed structures of the synthesized compounds were confirmed by IR and PMR spectroscopy. The antibacterial activity of some of the newly synthesized compounds was studied.Substituted tetrahydropyrrol-2,3-diones have previously been found to exhibit various types of biological activity [1]. It seemed interesting to introduce into the 1-position of the heterocycle a phenol group and to study how this might affect the antimicrobial activity of the resulting compounds. I (R 1 = Ph, R 2 = H), II (R 1 = CH 3 , R 2 = H), III (R 1 = CH 3 , R 2 = 4-Cl), IV (R 1 = Ph, R 2 = 4-Cl), V (R 1 = CH 3 , R 2 = 2-NO 2 ), VI (R 1 = CH 3 , R 2 = 2-OCH 3 ), VII (R 1 = CH 3 , R 2 = 4-CH 3 ), VIII (R 1 = CH 3 , R 2 = 3-NO 2 ), IX (R 1 = CH 3 , R 2 = 2-Cl), X (R 1 = CH 3 , R 2 = 2,5(OCH 3 ) 2 ), XI (R 1 = CH 3 , R 2 = 2-F), XII (R 1 = CH 3 , R 2 = 4-C 3 H 7 ), XIII (R 1 = CH 3 , R 2 = 4-NO 2 ), XIV (R 1 = CH 3 , R 2 = 3-OCH 3 ), XV (R 1 = CH 3 , R 2 = 3-OH), XVI (R 1 = CH 3 , R 2 = 4-F), XVII (R 1 = CH 3 , R 2 = 3-OCH 3 -4-OH), XVIII (R 1 = CH 3 , R 2 = 3-F), XIX (R 1 = Ph, R 2 = 3,4-(OCH 3 ) 2 ), XX (R 1 = Ph, R 2 = 2-NO 2 ), XXI (R 1 = Ph, R 2 = 3-NO 2 ), XXII (R 1 = 4-CH 3 , R 2 = 4-CH 3 ), XXIII (R 1 = 4-CH 3 , R 2 = Ph), XXIV (R 1 = 4-CH 3 , R 2 = 3-F), XXV (R 1 = 4-CH 3 , R 2 = 2-Cl), XXVI (R 1 = 4-CH 3 , R 2 = 4-NO 2 ), XXVII (R 1 = Ph, R 2 = Ph), XXVIII (R 1 = 4-CH 3 , R 2 = 4-F), XXIX (R 1 = 4-CH 3 , R 2 = 4-Br), XXX (R 1 = 4-CH 3 , R 2 = 4-OCH 3 ).
