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Summary: One hundred and seventy-five women took part in a comparative clinical trial of four progestogen-ouly oral contraceptives and were followed for either a year or until treatment was discontinued. Megestrol acetate 0-25 mg. was found to be a very ineffective contraceptive, 21 out of 43 women becoming pregnant. One, three, and four pregnancies occurred during treatment with norethisterone acetate 0'3 mg., norgestrel 0.05 mg., and chodinone 0-5 mg., respectively, corresponding to pregnancy rates of 4, 9, and 12 per 100 woman-years of use.All three effective progestogens were very much less acceptable than modern low-dose combined oral contraceptives. Discontinuation of treatment for medical reasons (particularly menstrual disturbances) during the course of only one year affected 24% receiving norethisterone acetate, 38% receiving norgestrel, and 46% receiving chlormiinone.

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To test the hypothesis that a combination therapy with dexamethasone and spironolactone in hirsute women with menstrual disorders due to non-tumorous hyperandrogenism might yield better results than monotherapy with spironolactone, we evaluated 25 women randomly assigned to dexamethasone-spironolactone (n = 15) and spironolactone (n = 10) groups. The Ferriman-Gallwey score and hormonal levels (LH, FSH, PRL, serum testosterone, androstenedione, dehydroepiandrosterone sulfate, estradiol, estrone and salivary testosterone) were determined before and after 6 months of therapy. There were comparable results, with a significant drop in the Ferriman-Gallwey score, in serum androstenedione and estrone concentrations and in salivary testosterone levels in both groups. The only difference between the two groups after therapy was a significant fall in serum dehydroepiandrosterone levels in patients treated with the combination therapy. The results indicate that the combination therapy with spironolactone and dexamethasone presents no real advantage over therapy with spironolactone alone, for the initial treatment of non-tumorous hyperandrogenism.

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The safety and effectiveness of flexible and nonflexible plastic cannulae used in vacuum aspiration abortion for patients at 6 to 12 weeks' gestation were evaluated in a study of 1100 physically healthy women in Ljublijana, Yugoslavia. To minimize study biases, each type of cannulae was randomly assigned to 550 patients. To minimize evaluator bias, a second physician who was kept unaware of which cannula was used for particular patient was responsible for evaluating patients after the procedures. Both groups of patients were similar with respect to age, parity, marital status, formal education and gestational age. Higher rates of retained tissue and cannula obstruction were obtained with the flexible cannula. The two types of cannulae were not significantly different with respect to other criteria of evaluation.