In recent years there has been an increasing trend in which data scientists and domain experts work together to tackle complex scientific questions. However, such collaborations often face challenges. In this paper, we aim to decipher this collaboration complexity through a semi-structured interview study with 22 interviewees from teams of bio-medical scientists collaborating with data scientists. In the analysis, we adopt the Olsons' four-dimensions framework proposed in Distance Matters to code interview transcripts. Our findings suggest that besides the glitches in the collaboration readiness, technology readiness, and coupling of work dimensions, the tensions that exist in the common ground building process influence the collaboration outcomes, and then persist in the actual collaboration process. In contrast to prior works' general account of building a high level of common ground, the breakdowns of content common ground together with the strengthen ofprocess common ground in this process is more beneficial for scientific discovery. We discuss why that is and what the design suggestions are, and conclude the paper with future directions and limitations.Mao and Wang, et al. models submitted by approximately 100 research groups worldwide and granted the top winner to a Data Science researcher team -Google's Deepmind's AlphaFold [15]. The success of these interdisciplinary collaborations is also appealing to Human-Computer Interaction (HCI) researchers and a few papers have been published in recent years (e.g., offline data hackathon for civic issues [41], or online data challenges such as in Kaggle.com [14]).However, besides these aforementioned success stories, there are also turbulences in these collaborations. Even in the case study reporting a successful offline data hackathon event, Hou and Wang [41] described a tension between the NPOs' expectations (domain experts) and the data volunteers' expectations (data scientists), which they described as a "dual goal" dilemma. In the more general open science and cyberinfrastructure contexts, tensions and challenges are not rarely seen, which have been attributed to the interdisciplinary nature of the team [94], related motivational factors [84] and cultural differences [9], the remote and cross-culture team structure [54,57], the data-centric practice [79], or the lack of technology and infrastructure support [66].These tensions are not new in the Computer-Supported Cooperative Work (CSCW) field. In their landmark paper, "Distance Matters", 20 years ago [65] Olson and Olson developed a coherent framework to describe a collaboration to be successful or not. It has four dimensions: Common Ground, Coupling of Work, Collaboration Readiness, and Technology Readiness. Though they were primarily looking at remote, not necessarily data-centric, scientific collaborations at that time (which they referred to collaboratories [103]), their framework has been proven to be effective in analyzing more general collaborations beyond the "remote" settings [43,64,[67][68][69].In t...