No abstract

No abstract

Noble crayfish (Astacus astacus) is listed as vulnerable by the IUCN Red List of Threatened Species in Europe. However, very little is known about genetic diversity and structuring of noble crayfish populations, mainly because of the lack of informative genetic markers. We describe the isolation and characterization of the first microsatellite markers for this species, which were obtained by screening 4,000 recombinant clones. Eight loci revealed polymorphisms in a panel of 172 individuals from seven populations in Northern Europe. Number of alleles per locus ranged from two to 10 (average 4.4) and heterozygosity levels among populations varied from 0 to 0.80 for H o and from 0 to 0.72 for H e .

No abstract

This work describes synthesis of CH 2-skipped alternating piperazine-pyridine cycles with azide end-group starting from piperazine, 1-methylpiperazine and pyridine-2,6-dicarboxylic acid. This compound can be used to enhance binding efficiency by shielding repulsion between negatively charged phosphate groups in DNA-oligonucleotide hybridization techniques. Piperazine derivatives are useful in the treatment or prevention of many diseases like inflammation, 1 bone degradation, 2 thrombosis 3 and tumor metastasis. 4 On the other hand oligomeric piperazine compounds could be source of potential positive charge which is important factor in interactions of small molecules with biological systems. Subsequent functionality and reactivity offer a good possibility to regulate hydrophilicity/hydrophobicity, geometry, π-interaction and as a result design the appropriate molecule for certain purposes.