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The aim of this article is to describe the first case of Hutchinson-Gilford Progeria Syndrome (HGPS) in Togo and review all Africans cases. Our patient was a 12.8-year-old Togolese boy followed in our unit till he was 15-year-old for HGPS. He was the only child of non-consanguineous parents. The phenotypic findings were craniofacial dysmorphy, dwarfism, lipodystrophy, diffusely scattered hyperpigmented foci, pyriform thorax, nail dystrophy, decreased joint mobility, and camptodactyly. He had characteristic facies with prominent forehead, prominent eyes, absent ear lobule, thin nasal skin, convex nasal profile, micrognathia, and crowded teeth. Radiologicals findings were bilateral coxa valga, pyriform thorax, and acro-osteolysis. We sequenced the entire coding region of LMNA gene, and mutation analysis revealed a heterozygous mutation c.1824C>T (p.Gly608Gly). Our patient is therefore the fifth African and the fourth with classical mutation, first of Western Africa, and second of (sub-Saharan) African black race. The recurrence of HGPS is low like the cause is neomutation or germinal mosaicism.

IntroductionLe but de l’étude était décrire les aspects épidémiologiques des conjonctivites néonatales dans le canton de Glidji au Sud du Togo.MethodesNous avons mené une étude transversale dans les 4 Unités Sanitaires Périphériques du canton de Glidji du 19 Mars au 13 Mai 2009 soit 8 semaines. Tous les nouveau-nés ont été inclus et la conjonctivite néonatale était définie par la présence chez un nouveau-né d'au moins deux des signes suivants: hyperhémie conjonctivale, œdème palpébral, chémosis, sécrétions purulentes, larmoiement. Les paramètres étudiés étaient l’âge, le sexe, les facteurs de risque, les antécédents, la présence ou non de conjonctivite, les germes en causes et l’évolution sous traitement.ResultatsSur la période, 159 nouveau-nés ont été examinés. L’âge moyen était de 10,9 jours avec des extrêmes de 0 à 28 jours. Il y avait 80 garçons pour 79 filles soit un sex-ratio de 1,01. Sur les 159 nouveau-nés, 7 cas de conjonctivite ont été diagnostiqués soit une prévalence de 4,4%. Les facteurs de risque identifiés étaient l'accouchement par voie basse et la présence d'IST chez la mère pendant la grossesse. Sur les 7 cas de conjonctivite, l'examen cytobactériologique a permis d'isoler le staphylococcus aureus dans 2 cas. L’évolution des cas de conjonctivite sous traitement était favorable avec régression des signes dès le 3è jour.ConclusionLes conjonctivites néonatales avaient une prévalence de 4,4% dans le canton de Glidji au sud du Togo et le staphylocoque doré était le germe en cause. Leur prévention passe par un bon suivi lors de la consultation prénatale et l'instillation de collyre antibiotique à la naissance

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Introduction: Glaucoma is a major cause of irreversible blindness worldwide. Early detection and awareness are essential to reduce the impact on eye health. The aim of this study is to assess the knowledge, attitudes and practices of health care staff about glaucoma in Lomé. Materials and Methods: This was a prospective cross-sectional and descriptive study including health care staff in Lomé, from October 1st to December 31st, 2020, for a period of 3 months. After their agreement, the officers responded to questions based on a survey sheet. Results: A total of 169 agents from 3 centers in Lomé, i.e. the Sylvanus Olympio University Teaching Hospital, the Campus University teaching Hospital and the Bè Hospital were involved. 50.9% of the agents were male versus 49.1% female, i.e. a ratio of 1.04. The average age was 33.66 ± 10.45 years. 46.10% were doctors versus 53.90% paramedics. 58.60% had at most 5 years of experience against 41.40% who had more than 5 years of experience. 53.80% defined glaucoma as ocular hypertension while 17.20% defined it as optic nerve disease. 46.20% did not know that there were many types of glaucomas compared to 53.20% who knew that there are many types of glaucomas. 92.30% knew that glaucoma can lead to cause visual loss. Regarding attitudes and practices about glaucoma, 91.70% declared that the follow-up should be done by the ophthalmologist, 81.10% thought that it would be necessary to be checked by the doctor only every 6 months. Finally, 65.08% declared that they had to use eye drops for life for the treatment. Conclusion:Steps should be taken to educate staff more about glaucoma attitudes and practices and also plan for action in the population.

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Aims: To describe clinical and etiological features of proptosis. Materials and methods:We have conducted a retrospective and descriptive study based on patient's records during 15 years, from January 2001 to December 2015. All patients went through a comprehensive ophthalmologic examination, and orbito-cerebral CT scan. T3, T4, TSH thyroid's hormone dosage was realized upon on the clinical request. The clinical features and the etiologies of proptosis were analyzed.Results: During the period, 46 cases of proptosis were identified. The mean age was 41.2 ± 18.8 [1;79] years. There were 15 men against 31 women with a sex ratio of 0.48. The proptosis was unilateral in 32 cases and bilateral in 14 cases. The proptosis was scaled as grade I was in 22 cases (47.8%), grade II in 20 cases (43.5%) and grade III in 4 cases (8.7%). The proptosis was axial in 38 cases (82.6%). It was painful in 21 cases (45.6%). It was reducible in 23 cases (50%) and pulsatile in one case (2.2%). The etiologies of the proptosis were hyperthyroidism in 16 cases (34.8%) , orbital cellulitis in 12 cases (26.1%), idiopathic orbital inflammatory disease in 9 cases (19.6%), orbital tumors in 8 cases (17.4%) and carotido-cavernous fistula in one case (2.1%). Women were more involved by hyperthyroidism (81.3%), and it was associated with a bilateral proptosis (81.3%), of grade II (68.8%), axial (93.8%) not painful (93.7%) and reducible (93.8%) Conclusion: proptosis is a relatively frequent symptom that can reveal several diseases, some of them can be life threatening.

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