Ocular tumors in Togo: epidemiological, clinical, and histopathological features observed at the Lomé Teaching Hospital of Sylvanus Olympio

Vonor, Kokou; Banla, M.; Darré, Tchin; Ayena, K.D.; Amégbor, Koffi; Dzidzinyo, K; Amedome, K.M.; Balo, K.P.

doi:10.1684/mst.2014.0418

Cited by 3 publications

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“…However, in Ghana, over half (51.3%) of the patients diagnosed with CSCC are female, and the median age is 46.5 years old, with some patients presenting as young as 20 years old. This is also consistent with some studies of CSCC performed in Eastern Africa that report that over half of their CSCC cohorts are female, with a mean age at diagnosis in the 30s to 50s. Additionally, in the general Ghanaian population, the proportion of people with HIV infection peaks between the ages of 35 to 45 years old, at approximately 3%.…”

Section: Discussionsupporting

confidence: 91%

“…After diagnosis, the most common symptoms included discharge, eye pain, and headache. This presentation is consistent with CSCC in the United States as well as in Africa . Additionally, 16/64 (25%) of the Ghanaian cohort had at least one constitutional symptom, and we observed a significant relationship between constitutional symptoms and HIV infection (chi‐squared test, P = 0.011).…”

Section: Discussionsupporting

confidence: 85%

“…Previous studies on CSCC in Africa describe that clinical characteristics of all ocular neoplasms do not separately analyze the characteristics of HIV+ and HIV− patients or are conducted in Eastern Africa . Additionally, other studies of CSCC in Africa report a higher rate of HIV infection in patients with CSCC than in the general population, ranging from 50% to 76.9% of the CSCC population with HIV infection . This was supported by the findings in our study, as 32/64 (50%) of the patients with CSCC are HIV+ while the incidence of HIV infection in Ghana is 1.47%.…”

Section: Discussionsupporting

confidence: 84%

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Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Merz

Afriyie

Jiagge

et al. 2019

Health Science Reports

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Background and aims Conjunctival squamous cell carcinoma (CSCC) varies in incidence geographically from 0 to 1 case per 100 000 per year globally. Additionally, the incidence of CSCC is known to increase 49% for every 10° decrease in latitude. Since the onset of the AIDS epidemic, there has been a trend of increasing incidence of CSCC in Africa, and despite relatively stable levels of ultraviolet (UV) exposure, there is an observed 12 times greater risk of developing CSCC when individuals are infected with HIV. In this study, we aim to analyze the clinical characteristics and biomarkers of CSCC in Ghana. Methods In this study, a registry review of patients from January 2011 to May 2016 with CSCC at Komfo‐Anokye Teaching Hospital in Kumasi, Ghana, was performed (n = 64). Tumor blocks of the CSCC were analyzed for the expression of various biomarkers. Results In this study, the median age of onset of CSCC is 46.5 years old (range of 20–90 y old). Fifty one and a half percent (n = 33) of the cohort is female. There is a low rate of smoking and alcohol use in our CSCC cohort. Thirty‐nine percent (n = 12) of Ghanaian men with CSCC are HIV−, while only 12% (n = 4) of women are HIV−. Fifteen patients had metastasis to lymph nodes or other tissues, and we observed a statistically significant relationship between HIV infection and metastasis (P = 0.027, chi‐squared test). We observed no statistically significant relationship between known prognostic CSCC biomarkers and HIV status, age, or tumor stage. Conclusion Better characterization of CSCC could have a profound impact on the prevention, early identification, and treatment of CSCC in Africa. A retrospective chart analysis and collection of tumor samples can be challenging in this region due to methods of record keeping and stigma attached to clinical data such as HIV testing and smoking and alcohol use. As a result, in this study, data were often incomplete leading to inconclusive results and analysis that should be interpreted with caution. Future studies should consider a prospective study design that gathers clinical data in a standardized format and ensures fresh tissue from CSCC tumors.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Merz

Afriyie

Jiagge

et al. 2019

Health Science Reports

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Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Bile,

Djiguimde,

Diomandé

et al. 2024

OJOph

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Epidemioclinical and Histological Profile of Malignant Ocular Tumors at University Hospital Center of Bouake

BILE

2024

JOAR

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Objective: To describe the epidemiological, clinical and histopathological aspects of malignant tumors in the Gbêkê region. Materials and methods: Retrospective cross-sectional descriptive study conducted in the ophthalmology department of the Bouake University Hospital over a 5-year period [January 1, 2018, to December 31, 2022]. It involved patients seen in consultation for malignant ocular tumors confirmed after clinical and paraclinical examination. Results: Prevalence was 0.19%. The mean age was 31.52 years, with extremes of 4 months and 72 years. Reasons for consultation were dominated by exophthalmos (41.67%). Most patients (77.08%) had a consultation delay of over 12 months. The conjunctiva was the preferred site of ocular malignancies (41.67%). Squamous cell carcinoma was the most common tumour of all ages, accounting for 41.66%. Squamous cell carcinoma was the most common malignancy in adults, with 55.56%. In children, retinoblastoma remains the most common tumor (58.33%).

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Ocular tumors in Togo: epidemiological, clinical, and histopathological features observed at the Lomé Teaching Hospital of Sylvanus Olympio

Cited by 3 publications

References 0 publications

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Epidemioclinical and Histological Profile of Malignant Ocular Tumors at University Hospital Center of Bouake

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