There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis.
and serological testing 37 (6) No evidence of mycobacterial cell wall by histochemical staining (7) No worsening of Crohn's disease with immunosuppressive agents or HIV infection (8) No documented cell mediated immune responses to MAP in patients with Crohn's disease 20 (9) No therapeutic response to traditional antimycobacterial antibiotics 23 MAP, Mycobacterium avium subspecies paratuberculosis; PCR, polymerase chain reaction; FISH, fluorescent in situ hybridisation; HIV, human immunodeficiency virus.
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