Combined carriership ofTLR9-1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis

Abstract

There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis.

A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection

“…Polymorphisms of the gene of flagellin-binding TLR5 are associated with susceptibility to Legionnaires' disease [29]. TLR9 binds bacterial and viral CpG-DNA and polymorphisms have been implicated in autoimmune and allergic disorders [30][31][32][33][34]. Although TLR9 stimulation shows antiviral effects in HCV-infection [35], binding to TLR9 has only been demonstrated for DNA viruses [36] and binding of HCV to TLR9 is unlikely.…”

Both Preoperative Perinuclear Antineutrophil Cytoplasmic Antibody and Anti-CBir1 Expression in Ulcerative Colitis Patients Influence Pouchitis Development After Ileal Pouch–Anal Anastomosis

“…CBir1 flagellin interacts with its tolllike receptor (TLR5) leading to activation of nuclear factor kappa-beta and the subsequent transcriptional induction of many proinflammatory cytokines (34,35). The detection of antibodies to CBir1 in patients with pouchitis should not be unexpected as there appears to be an association between both TLR allele carriage and mucosal TLR expression in patients with pouchitis (36,37).…”

Genetics of the innate immune response in inflammatory bowel disease

“…236 In a recent study, a combined carriership of the alleles TLR9-237C and CD14-260T was increased in the chronic relapsing pouchitis group when compared with UC patients with infrequent pouchitis. 242 …”